{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:49:41Z","timestamp":1790394581536,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Duodenal bile crystal analysis for the detection of gallstones was assessed in 26 patients with acute pancreatitis of known aetiology (11 attributable to gallstones and 15 to alcohol) and in 37 patients without a history of acute pancreatitis (21 with gallstones and 16 without). The sensitivity was 64\u201367 per cent and the specificity was 94\u2013100 per cent in these groups. Analysis of duodenal bile from 14 patients with \u2018idiopathic\u2019 pancreatitis revealed calcium bilirubinate crystals (but not cholesterol crystals) in 5 patients (36 per cent). Gallstones were confirmed at cholecystectomy in three of these patients and also in one other patient who had a gallstone on a \u2018late\u2019 ultrasound examination but was negative for crystals. Thus 29 per cent of the original \u2018idiopathic\u2019 group had gallstones confirmed. Gallstone analysis showed that pigment stones were present in 7 of 31 (23 per cent) non-pancreatitis controls compared with 9 of 13 (69 per cent) pancreatitis patients (P = 0\u00b70048). These results suggest that duodenal bile crystal analysis (involving both calcium bilirubinate and cholesterol crystals) may be a useful technique for the investigation of patients with \u2018idiopathic\u2019 pancreatitis.<\/jats:p>","DOI":"10.1002\/bjs.1800750517","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:49:56Z","timestamp":1172918996000},"page":"450-453","source":"Crossref","is-referenced-by-count":72,"title":["Role of duodenal bile crystal analysis in the investigation of \u2018idiopathic\u2019 pancreatitis"],"prefix":"10.1093","volume":"75","author":[{"given":"J P","family":"Neoptolemos","sequence":"first","affiliation":[{"name":"Department of Surgery, The Leicester Royal Infirmary , Leicester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Leicester Royal Infirmary , Leicester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Winder","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, The Leicester Royal Infirmary , Leicester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vallance","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Leicester Royal Infirmary , Leicester,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"2024092806062975900_bib1","first-page":"184","article-title":"Mortality in acute pancreatitis","volume":"66","author":"De Bolla","year":"1984","journal-title":"Ann R Coll Surg Engl"},{"key":"2024092806062975900_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(85)92733-3","article-title":"Prediction of severity in acute pancreatitis: prospective comparison of three prognostic indices","volume":"ii","author":"Corfield","year":"1985","journal-title":"Lancet"},{"key":"2024092806062975900_bib3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/gut.26.7.724","article-title":"Acute pancreatitis: A lethal disease of increasing incidence","volume":"26","author":"Corfield","year":"1985","journal-title":"Gut"},{"key":"2024092806062975900_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/gut.26.2.125","article-title":"Detection of gallstones after acute pancreatitis","volume":"26","author":"Goodman","year":"1985","journal-title":"Gut"},{"key":"2024092806062975900_bib5","first-page":"104","article-title":"Acute pancreatitis in North and North-East Scotland","volume":"30","author":"Thomson","year":"1985","journal-title":"J R Coll Surg Edinb"},{"key":"2024092806062975900_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/bjs.1800710324","article-title":"The urgent diagnosis of gallstones in acute pancreatitis: a prospective study of three methods","volume":"71","author":"Neoptolemos","year":"1984","journal-title":"Br J Surg"},{"key":"2024092806062975900_bib7","first-page":"354","article-title":"Endoscopic retrograde cholangiopancreatography after acute pancreatitis","volume":"163","author":"Lee","year":"1986","journal-title":"Surg Gynecol Obstet"},{"key":"2024092806062975900_bib8","first-page":"179","article-title":"Operations upon the biliary tract in patients with acute pancreatitis: aims, indications and timing","volume":"66","author":"Mayer","year":"1984","journal-title":"Ann R Coll Surg Engl"},{"key":"2024092806062975900_bib9","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/archsurg.1976.01360280064010","article-title":"Gallstone pancreatitis: Explorations of the biliary system in acute and recurrent pancreatitis","volume":"111","author":"Freund","year":"1976","journal-title":"Arch Surg"},{"key":"2024092806062975900_bib10","first-page":"905","article-title":"Gallstones and acute pancreatitis\u2014is the association underestimated? 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