{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:19:02Z","timestamp":1783138742724,"version":"3.54.6"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hydroxyethyl starch (HES) is a recently developed synthetic volume expander. Forty patients undergoing coronary artery surgery were randomized to receive either HES or plasma protein fraction (PPF) as non-blood volume replacement according to standard haemodynamic criteria. The two groups were comparable in all respects. The median colloid use in the first 24 h was 950 ml (range 500\u20131500) in the HES group and 975 ml (350\u20132000) in the PPF group (not significant). There was no difference in blood use, urine output or blood loss between the two groups. Tests of coagulation showed the postoperative changes usual in cardiac surgical patients. There was no difference between the two groups in thrombin time, prothrombin time, activated partial thromboplastin time, or fibrinogen concentration. Similarly, tests of platelet function and Factor VIII and von Willebrand Factor activity showed no difference between the two groups. We conclude that HES is a safe and effective volume expander, and its relative lack of expense and ease of availability make its routine use after cardiac surgery an attractive proposition.<\/jats:p>","DOI":"10.1002\/bjs.1800750717","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T11:00:07Z","timestamp":1172919607000},"page":"675-678","source":"Crossref","is-referenced-by-count":53,"title":["Hydroxyethyl starch: an alternative to plasma for postoperative volume expansion after cardiac surgery"],"prefix":"10.1093","volume":"75","author":[{"given":"C M","family":"Munsch","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Middlesex Hospital , London W1,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Maclntyre","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Middlesex Hospital , London W1,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Machin","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Middlesex Hospital , London W1,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I J","family":"Mackie","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Middlesex Hospital , London W1,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Treasure","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Middlesex Hospital , London W1,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"2024092806112339100_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/00000658-196611000-00017","article-title":"Effect of hydroxyethyl starch on plasma volume and haematocrit following haemorrhagic shock in dogs. Comparison with dextran, plasma and ringer","volume":"164","author":"Vineyard","year":"1966","journal-title":"Ann Surg"},{"key":"2024092806112339100_bib2","first-page":"33","article-title":"The effect of hydroxyethyl starch upon survival of dogs submitted to haemorrhagic shock","volume":"122","author":"Ballinger","year":"1966","journal-title":"Surg Gynecol Obstet"},{"key":"2024092806112339100_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00003246-198005000-00007","article-title":"Haemodynamic, blood volume, and oxygen transport responses to albumin and hydroxyethyl starch infusions in critically ill postoperative patients","volume":"8","author":"Lazrove","year":"1980","journal-title":"Crit Care Med"},{"key":"2024092806112339100_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005373-196805000-00005","article-title":"Clinical evaluation of a new plasma expander, hydroxyethyl starch","volume":"8","author":"Lee","year":"1968","journal-title":"J Trauma"},{"key":"2024092806112339100_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/bmj.3.5621.783","article-title":"Clinical trial of 5% hydroxyethyl starch (a new plasma expander)","volume":"3","author":"Solanke","year":"1968","journal-title":"Br Med J"},{"key":"2024092806112339100_bib6","first-page":"670","article-title":"Increased blood loss associated with administration of certain plasma expanders: dextran 75, dextran 40, and hydroxyethyl starch","volume":"62","author":"Karlson","year":"1967","journal-title":"Surgery"},{"key":"2024092806112339100_bib7","volume-title":"A Laboratory Manual of Blood Coagulation","author":"Austen","year":"1976"},{"key":"2024092806112339100_bib8","volume-title":"Bleeding Disorder\u2014Investigation and Management","author":"Hardisty","year":"1965"},{"key":"2024092806112339100_bib9","volume-title":"Human Blood Coagulation, Haemostasis and Thrombosis","author":"Biggs","year":"1976"},{"key":"2024092806112339100_bib10","first-page":"67","article-title":"Quantitative investigations into the aggregation of blood platelets","volume":"162","author":"Born","year":"1962","journal-title":"J Physiol"},{"key":"2024092806112339100_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(66)90246-6","article-title":"Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies","volume":"15","author":"Laurell","year":"1966","journal-title":"Anal Biochem"},{"key":"2024092806112339100_bib12","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1172\/JCI107465","article-title":"Quantitative assay for a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation","volume":"52","author":"Weiss","year":"1983","journal-title":"J Clin Invest"},{"key":"2024092806112339100_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1056\/NEJM198207083070201","article-title":"A platelet inhibitor drug trial in coronary artery bypass operations: benefit of perioperative dipyridamole and aspirin therapy on early postoperative vein graft patency","volume":"307","author":"Cheseboro","year":"1982","journal-title":"N Engl J Med"},{"key":"2024092806112339100_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0003-4975(10)60927-7","article-title":"Influence of aspirin and dipyridamole on patency of coronary artery bypass grafts","volume":"31","author":"Mayer","year":"1981","journal-title":"Ann Thorac Surg"},{"key":"2024092806112339100_bib15","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0022-5223(19)43380-1","article-title":"Blood volume and body fluid compartment changes soon after closed and open intracardiac surgery","volume":"52","author":"Cleland","year":"1966","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092806112339100_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0308-2261(18)30034-1","article-title":"Synthetic plasma volume expanders\u2014their pharmacology, safety and clinical efficacy","volume":"13","author":"Mishler","year":"1984","journal-title":"Clin Haematol"},{"key":"2024092806112339100_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(77)91953-5","article-title":"Incidence and severity of anaphylactoid reactions to colloid volume substitutes","volume":"i","author":"Ring","year":"1977","journal-title":"Lancet"},{"key":"2024092806112339100_bib18","volume-title":"Pharmacology of Hydroxyethyl Starch. Use in Therapy and Blood Banking","author":"Mishler","year":"1982"},{"key":"2024092806112339100_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/oxfordjournals.bmb.a071441","article-title":"Physiological mechanisms in coagulation and fibrinolysis","volume":"33","author":"Brozovic","year":"1977","journal-title":"Br Med Bull"},{"key":"2024092806112339100_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2141.1981.tb07197.x","article-title":"Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentration","volume":"49","author":"Lombardi","year":"1981","journal-title":"Br J Haematol"},{"key":"2024092806112339100_bib21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0022-5223(19)40913-6","article-title":"Cardiopulmonary bypass. Associated haemostatic abnormalities","volume":"77","author":"Kalter","year":"1979","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092806112339100_bib22","first-page":"22","article-title":"Editorial. Haemostatic factors and coronary heart disease","volume":"i","year":"1981","journal-title":"Lancet"},{"key":"2024092806112339100_bib23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/238288a0","article-title":"Dextrans and fibrin morphology","volume":"238","author":"Muzaffar","year":"1972","journal-title":"Nature"},{"key":"2024092806112339100_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF00273540","article-title":"The haemostatic effects of hydroxyethyl starch used as a volume expander","volume":"11","author":"MacIntyre","year":"1985","journal-title":"Intensive Care Med"},{"key":"2024092806112339100_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003246-198203000-00004","article-title":"Colloid osmotic pressure and fluid resuscitation with hetastarch, albumin and saline solutions","volume":"10","author":"Haupt","year":"1982","journal-title":"Crit Care Med"},{"key":"2024092806112339100_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/cs068027Pa","article-title":"Hydroxyethyl starch increases colloid osmotic pressure and central venous pressure in critically ill patients","volume":"68","author":"Barclay","year":"1985","journal-title":"Clin Sci"},{"key":"2024092806112339100_bib27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0003-4975(10)60908-3","article-title":"Hetastarch as a prime for cardiopulmonary bypass","volume":"34","author":"Palanzo","year":"1982","journal-title":"Ann Thorac Surg"},{"key":"2024092806112339100_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-5223(19)39512-1","article-title":"Hydroxethyl starch in priming fluid for cardioputmonary bypass","volume":"84","author":"Sade","year":"1982","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092806112339100_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000127896","article-title":"Intravascular persistence of hydroxyethyl starch in man","volume":"8","author":"Boon","year":"1976","journal-title":"Eur Surg Res"},{"key":"2024092806112339100_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/j.1552-4604.1982.tb02164.x","article-title":"Pharmacokinetics of hydroxyethyl starch in normal subjects","volume":"22","author":"Yacobi","year":"1982","journal-title":"J Clin Pharmacol"},{"key":"2024092806112339100_bib31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0003-4975(10)60907-1","article-title":"Clinical comparison of hetastarch and albumin in postoperative cardiac patients","volume":"34","author":"Diehl","year":"1982","journal-title":"Ann Thorac Surg"},{"key":"2024092806112339100_bib32","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/00003246-198312000-00009","article-title":"Haemodynamic comparison of albumin and hydroxyethyl starch in postoperative cardiac surgery patients","volume":"11","author":"Moggio","year":"1983","journal-title":"Crit Care Med"},{"key":"2024092806112339100_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0003-4975(10)60707-2","article-title":"Hydroxyethyl starch versus albumin for colloid infusion following cardiopulmonary bypass in patients undergoing myocardial revascularization","volume":"37","author":"Kirklin","year":"1984","journal-title":"Ann Thorac Surg"},{"key":"2024092806112339100_bib34","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00003246-198112000-00006","article-title":"Hydroxyethyl starch for resuscitation of patients with hypovolaemia and shock","volume":"9","author":"Puri","year":"1981","journal-title":"Crit Care Med"},{"key":"2024092806112339100_bib35","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/archsurg.1983.01390070016004","article-title":"Efficacy of hetastarch in the resuscitation of patients with multisystem trauma and shock","volume":"118","author":"Shatney","year":"1983","journal-title":"Arch Surg"},{"key":"2024092806112339100_bib36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00000542-198705000-00030","article-title":"Hetastarch coagulopathy in a neurosurgical patient","volume":"66","author":"Cully","year":"1987","journal-title":"Anesthesiology"},{"key":"2024092806112339100_bib37","volume-title":"Monthly Index of Medical Specialities (MIMS)","year":"1987"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800750717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/75\/7\/675\/59386902\/bjs1800750717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/75\/7\/675\/59386902\/bjs1800750717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T06:11:35Z","timestamp":1727503895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/75\/7\/675\/6183809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7,1]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1988,7,1]]},"published-print":{"date-parts":[[1988,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800750717","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,7]]},"published":{"date-parts":[[1988,7,1]]}}}