{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:58:32Z","timestamp":1769551112898,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>From 1975 to 1987, 507 patients, of whom 63 (12.4 per cent) were over 55 years old at the time of operation, received first cadaver renal transplants. The annual percentage of recipients given transplants after the age of 55 has risen from 0 per cent in 1975 to 44 per cent in 1987. Of the 63 older patients, 41 had at least one serious non-renal disease at the time of transplantation. Perioperative mortality rate was 3 per cent. After successful transplantation these patients remained subject to a significant number of serious complications, even in the cyclosporin era. Despite these adverse factors, actuarial graft survival for the population over 55 years of age was no worse than for those patients receiving first cadaver grafts who were under 55 years old, although patient survival was poorer in the former group (P = 0.027). Analysis of the subgroup of 56 patients treated with an immunosuppression protocol containing cyclosporin failed to show any adverse effect of age on either graft or patient survival. It is concluded that renal transplantation can be as successful in patients over 55 years of age as it is in younger patients and, given an adequate supply of kidneys, should be considered the treatment of choice for the elderly patient with end-stage renal failure.<\/jats:p>","DOI":"10.1002\/bjs.1800751014","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:47:16Z","timestamp":1172918836000},"page":"984-987","source":"Crossref","is-referenced-by-count":17,"title":["Renal transplantation in patients over 55 years old"],"prefix":"10.1093","volume":"75","author":[{"given":"G","family":"Lauffer","sequence":"first","affiliation":[{"name":"Nuffield Department of Surgery (Transplant Unit), University of Oxford, Churchill Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Murie","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery (Transplant Unit), University of Oxford, Churchill Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gray","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery (Transplant Unit), University of Oxford, Churchill Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ting","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery (Transplant Unit), University of Oxford, Churchill Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Morris","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery (Transplant Unit), University of Oxford, Churchill Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,10,1]]},"reference":[{"key":"2024092719522983100_bib1","first-page":"33","volume-title":"Kidney Transplantation\u2014Principles and Practice","author":"Thompson","year":"1984","edition":"2nd"},{"key":"2024092719522983100_bib2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(78)91988-8","article-title":"Renal transplantation. A new unit's experience","volume":"ii","author":"Morris","year":"1978","journal-title":"Lancet"},{"key":"2024092719522983100_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0140-6736(80)90234-2","article-title":"A powerful effect of HLA-DR matching on survival of cadaveric renal allografts","volume":"ii","author":"Ting","year":"1980","journal-title":"Lancet"},{"key":"2024092719522983100_bib4","first-page":"323","volume-title":"Kidney Transplantation\u2014Principles and Practice","author":"Opelz","year":"1984","edition":"2nd"},{"key":"2024092719522983100_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(82)92042-6","article-title":"Low dose oral prednisolone in renal transplantation","volume":"i","author":"Morris","year":"1982","journal-title":"Lancet"},{"key":"2024092719522983100_bib6","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/bjs.1800741015","article-title":"Urological complications in 600 consecutive renal transplants","volume":"74","author":"Jaskowski","year":"1987","journal-title":"Br J Surg"},{"key":"2024092719522983100_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00007890-198309000-00009","article-title":"A controlled trial of cyclosporin in renal transplantation with conversion to azathioprine and prednisolone after three months","volume":"36","author":"Morris","year":"1983","journal-title":"Transplantation"},{"key":"2024092719522983100_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/bjs.1800750104","article-title":"Triple therapy in cadaver renal transplantation","volume":"75","author":"Jones","year":"1988","journal-title":"Br J Surg"},{"key":"2024092719522983100_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0140-6736(87)90233-9","article-title":"Cyclosporin conversion versus conventional immunosuppression: long-term follow-up and histological evaluation","volume":"i","author":"Morris","year":"1987","journal-title":"Lancet"},{"key":"2024092719522983100_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomised clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto","year":"1977","journal-title":"Br J Cancer"},{"key":"2024092719522983100_bib11","first-page":"111","article-title":"High risk patients in renal transplantation","volume":"9","author":"Najarian","year":"1977","journal-title":"Transplant Proc"},{"key":"2024092719522983100_bib12","first-page":"33","article-title":"Renal transplantation in patients over 50 years of age","volume":"13","author":"Sommer","year":"1981","journal-title":"Transplant Proc"},{"key":"2024092719522983100_bib13","first-page":"821","article-title":"Leichennierentransplantation bei Patienten uber 55 Jahren","volume":"74","author":"Von Thiel","year":"1981","journal-title":"Z Urol Nephrol"},{"key":"2024092719522983100_bib14","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1136\/bmj.286.6383.2018","article-title":"Successful treatment of middle aged and elderly patients with end stage renal disease","volume":"286","author":"Taube","year":"1983","journal-title":"Br Med J"},{"key":"2024092719522983100_bib15","first-page":"1","volume-title":"Progress in Transplantation","author":"Ost","year":"1985"},{"key":"2024092719522983100_bib16","first-page":"1046","article-title":"Primary renal transplantation in patients 50 years of age and older","volume":"15","author":"Okiye","year":"1983","journal-title":"Transplant Proc"},{"key":"2024092719522983100_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1056\/NEJM198801283180406","article-title":"Effect of transplantation on the Medicare End-stage Renal Disease Program","volume":"318","author":"Eggers","year":"1988","journal-title":"N Engl J Med"},{"key":"2024092719522983100_bib18","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1056\/NEJM198605083141904","article-title":"A randomized clinical trial of cyclosporin in cadaveric renal transplantation: analysis at three years","volume":"314","author":"The Canadian Multicentre Transplant Study Group","year":"1986","journal-title":"N Engl J Med"},{"key":"2024092719522983100_bib19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0002-9610(76)90387-1","article-title":"Technical considerations in elderly renal allograft recipients","volume":"132","author":"Geis","year":"1976","journal-title":"Am J Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800751014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/75\/10\/984\/59385184\/bjs1800751014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/75\/10\/984\/59385184\/bjs1800751014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T19:54:19Z","timestamp":1727466859000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/75\/10\/984\/6183674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,1]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1988,10,1]]},"published-print":{"date-parts":[[1988,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800751014","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,10]]},"published":{"date-parts":[[1988,10,1]]}}}