{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T04:04:19Z","timestamp":1727582659082},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1989,2,1]],"date-time":"1989-02-01T00:00:00Z","timestamp":602294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A prospective study was carried out in 428 subjects (212 controls and 216 patients) to evaluate the delayed cell-mediated immune response preoperatively in patients with biliary lithiasis. The delayed hyper-sensitivity response was assessed by a Multitest and subjects were classified as immunocompetent, relatively anergic or anergic. Significant differences were found between control subjects and patients with cholelithiasis compared with those with acute cholecystitis (P &amp;lt; 0\u00b701), non-icteric choledocholithiasis (P &amp;lt; 0\u00b701) and choledocholithiasis with jaundice (P &amp;lt; 0\u00b705). There were also differences between patients with icteric and non-icteric choledocholithiasis (P &amp;lt; 0\u00b702). Seven possible causative factors for anergy were evaluated: a haemoglobin concentration of \u2a7d 12 g\/l and a haematocrit of \u2a7d 35 per cent were related to the appearance of anergy and relative anergy in patients with acute cholecystitis. Bilirubin levels \u2a7e 34 \u03bcmol\/l were found in 60 per cent of patients with choledocholithiasis and relative anergy and in 80 per cent of those who were anergic (P &amp;lt; 0\u00b7001). These results show a high incidence of failure of the cell-mediated immune response in patients with acute cholecystitis (71 per cent) and icteric choledocholithiasis (82 per cent). In the latter, jaundice appears to be associated with this failure. A close correlation between relatively anergic and anergic state and the development of postoperative septic complications was found.<\/jats:p>","DOI":"10.1002\/bjs.1800760222","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:50:09Z","timestamp":1172926209000},"page":"169-172","source":"Crossref","is-referenced-by-count":7,"title":["Anergy in patients with biliary lithiasis"],"prefix":"10.1093","volume":"76","author":[{"given":"M","family":"Ca\u00ednzos","sequence":"first","affiliation":[{"name":"Service of General Surgery, Hospital General de Galicia , C\/Galeras s.n, Santiago de Compostela,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Potel","sequence":"additional","affiliation":[{"name":"Service of General Surgery, Hospital General de Galicia , C\/Galeras s.n, Santiago de Compostela,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Puente","sequence":"additional","affiliation":[{"name":"Service of General Surgery, Hospital General de Galicia , C\/Galeras s.n, Santiago de Compostela,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,2,1]]},"reference":[{"key":"2024092806215974300_bib1","first-page":"349","article-title":"The delayed hypersensitivity response: application in clinical surgery","volume":"82","author":"Pietsch","year":"1977","journal-title":"Surgery"},{"key":"2024092806215974300_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00000658-197709000-00002","article-title":"Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma","volume":"186","author":"Meakins","year":"1977","journal-title":"Ann Surg"},{"key":"2024092806215974300_bib3","first-page":"78","article-title":"Delayed hypersentivity in surgical patients: a mechanism for anergy","volume":"86","author":"Christou","year":"1979","journal-title":"Surgery"},{"key":"2024092806215974300_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0002-9610(79)90127-2","article-title":"Role of delayed hypersensitivity in predicting postoperative morbidity to mortality","volume":"137","author":"Johnson","year":"1979","journal-title":"Am J Surg"},{"key":"2024092806215974300_bib5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/archsurg.1984.01390200005001","article-title":"Surgical complications and skin test reactivity in patients with inflammatory bowel disease","volume":"119","author":"Heimmann","year":"1984","journal-title":"Arch Surg"},{"key":"2024092806215974300_bib6","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/BF01655198","article-title":"Two techniques of the delayed hypersensitivity skin test response for the assessment of bacterial host resistance","volume":"9","author":"Christou","year":"1985","journal-title":"World J Surg"},{"key":"2024092806215974300_bib7","first-page":"563","article-title":"The predictive role of delayed cutaneous hypersensitivity testing in postoperative complications","volume":"162","author":"Schackert","year":"1986","journal-title":"Surg Gynecol Obstet"},{"key":"2024092806215974300_bib8","article-title":"Correlation between anergy and postoperative sepsis in surgical patients. 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