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Therapy consisted of from two to five tablets of 50 mg levamisole (or placebo) twice a week, depending on bodyweight for 1 year. Levamisole was generally well tolerated, with only four reversible cases of agranulocytosis reported among 129 patients. The trial failed to show a benefit of levamisole on disease-free survival (P = 0\u00b753) or on survival (P = 0\u00b735). There was no difference between the two treatment groups in terms of number of disease relapses, sites of relapse, or time to relapse. The proportion of patients still alive at 5 years was 51 per cent (standard error, 5\u00b75 per cent) in the levamisole group versus 39 per cent (standard error, 5\u00b74 per cent) in the placebo group.<\/jats:p>","DOI":"10.1002\/bjs.1800760322","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:53:36Z","timestamp":1172926416000},"page":"284-289","source":"Crossref","is-referenced-by-count":64,"title":["Adjuvant therapy of poor prognosis colon cancer with levamisole: Results of an EORTC double-blind randomized clinical trial"],"prefix":"10.1093","volume":"76","author":[{"given":"J-P","family":"Arnaud","sequence":"first","affiliation":[{"name":"C.M.C.O. , Strasbourg,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Buyse","sequence":"additional","affiliation":[{"name":"C.M.C.O., European Organization for Research and Treatment of Cancer Data Center ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Nordlinger","sequence":"additional","affiliation":[{"name":"C.M.C.O., H\u01d2spital Saint-Antoine , Paris,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Martin","sequence":"additional","affiliation":[{"name":"C.M.C.O., INSERM Unit\u00e9 252 , Dijon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-C","family":"Pector","sequence":"additional","affiliation":[{"name":"C.M.C.O., Institut Jules Bordet , Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Zeitoun","sequence":"additional","affiliation":[{"name":"C.M.C.O., C.H.U. 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