{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:41Z","timestamp":1791928961870,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Cardiovascular Disease Educational and Research Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A unifying pathophysiological hypothesis states that the plasminogen activating activity (PAA) of the peritoneal mesothelium determines whether the fibrin which forms after peritoneal injury is either lysed or organized into permanent fibrous adhesions. The PAA of human peritoneal biopsies was measured using a fibrin plate lysis technique to assess the changes that occur in inflammation and ischaemia, conditions which both produce fibrous adhesions. Activity was found in all biopsies from normal parietal and visceral (appendix, bowel and omentum) peritoneum with no significant site-to-site variation. Inflamed peritoneum (parietal, appendicular and mesenteric) had significantly less PAA compared with normal peritoneum; visceral ischaemia also resulted in a significant decrease of PAA. These reductions in human peritoneal PAA observed in inflammation and ischaemia support the view that mesothelial PAA plays a key part in the prevention of events leading to the production of fibrous adhesions.<\/jats:p>","DOI":"10.1002\/bjs.1800760422","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:52:35Z","timestamp":1172926355000},"page":"382-384","source":"Crossref","is-referenced-by-count":113,"title":["Reduced human peritoneal plasminogen activating activity: Possible mechanism of adhesion formation"],"prefix":"10.1093","volume":"76","author":[{"given":"J N","family":"Thompson","sequence":"first","affiliation":[{"name":"Academic Surgical Unit, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Paterson-Brown","sequence":"additional","affiliation":[{"name":"Academic Surgical Unit, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Harbourne","sequence":"additional","affiliation":[{"name":"Irvine Vascular Laboratory, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Whawell","sequence":"additional","affiliation":[{"name":"Irvine Vascular Laboratory, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kalodiki","sequence":"additional","affiliation":[{"name":"Academic Surgical Unit, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A F","family":"Dudley","sequence":"additional","affiliation":[{"name":"Academic Surgical Unit, St. Mary's Hospital Medical School , London W2 1PG,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"2024092806375513300_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0002-9610(73)80123-0","article-title":"Peritoneal adhesions and their relation to abdominal surgery","volume":"126","author":"Weibel","year":"1973","journal-title":"Am J Surg"},{"key":"2024092806375513300_bib2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00000658-195511000-00006","article-title":"Intestinal obstruction caused by adhesions: a review of 388 cases","volume":"142","author":"Perry","year":"1955","journal-title":"Ann Surg"},{"key":"2024092806375513300_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/bjs.1800690502","article-title":"The causes and prevention of intestinal adhesions","volume":"69","author":"Ellis","year":"1982","journal-title":"Br J Surg"},{"key":"2024092806375513300_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00000658-197802000-00017","article-title":"Critical operative management of small bowel obstruction","volume":"187","author":"Stewardson","year":"1978","journal-title":"Ann Surg"},{"key":"2024092806375513300_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/bjs.1800520616","article-title":"The healing of peritoneum under normal and abnormal conditions","volume":"52","author":"Ellis","year":"1965","journal-title":"Br J Surg"},{"key":"2024092806375513300_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0022-4804(76)90064-0","article-title":"A physiological basis for the adhesion-free healing of deperitonealized surfaces","volume":"21","author":"Buckman","year":"1976","journal-title":"J Surg Res"},{"key":"2024092806375513300_bib7","first-page":"659","article-title":"Regeneration of the peritoneum: a fibrinolytic study","volume":"129","author":"Raftery","year":"1979","journal-title":"J Anat"},{"key":"2024092806375513300_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0002-9610(73)90011-1","article-title":"Serosal hypofibrinolysis: a cause of postoperative adhesions","volume":"125","author":"Gervin","year":"1973","journal-title":"Am J Surg"},{"key":"2024092806375513300_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000128208","article-title":"Effect of peritoneal trauma on peritoneal fibrinolytic activity and intraperitoneal adhesion formation: an experimental study in the rat","volume":"13","author":"Raftery","year":"1981","journal-title":"Eur Surg Res"},{"key":"2024092806375513300_bib10","first-page":"345","article-title":"Plasminogen activator content of human colon tumours and normal mucosae: separation of enzymes and partial purification","volume":"65","author":"Corasanti","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"2024092806375513300_bib11","first-page":"477","article-title":"Immunological characterisation of plasminogen activities in human tissues and body fluids","volume":"97","author":"Rijken","year":"1981","journal-title":"J Lab Clin Med"},{"key":"2024092806375513300_bib12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0003-9861(52)90121-5","article-title":"The fibrin plate method for estimating fibrinolytic activity","volume":"40","author":"Astrup","year":"1952","journal-title":"Arch Biochem Biophys"},{"key":"2024092806375513300_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-230X(08)60028-7","article-title":"Plasminogen activators, tissue degradation, and cancer","volume":"44","author":"Dano","year":"1985","journal-title":"Adv Cancer Res"},{"key":"2024092806375513300_bib14","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/0006-2952(84)90536-7","article-title":"Coronary thrombolysis: pharmacological considerations with emphasis on tissue-type plasminogen activator (t-PA)","volume":"33","author":"Fox","year":"1984","journal-title":"Biochem Pharmacol"},{"key":"2024092806375513300_bib15","first-page":"841","article-title":"Content and characterisation of plasminogen activators in lung tumours and normal lung tissue","volume":"40","author":"Markus","year":"1980","journal-title":"Cancer Res"},{"key":"2024092806375513300_bib16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/jcp.34.6.625","article-title":"Method of measuring fibrinolytic activity in a single layer of cells","volume":"34","author":"Raftery","year":"1981","journal-title":"J Clin Pathol"},{"key":"2024092806375513300_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/path.1711360404","article-title":"The mesothelium: its fibrinolytic properties","volume":"136","author":"Whitaker","year":"1982","journal-title":"J Pathol"},{"key":"2024092806375513300_bib18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/path.1700870221","article-title":"Fibrinolytic activity of reparative connective tissue","volume":"87","author":"Kwaan","year":"1964","journal-title":"J Path Bact"},{"key":"2024092806375513300_bib19","first-page":"623","article-title":"Fibrinolytic activity in serosal and synovial membranes","volume":"88","author":"Myhre-Jensen","year":"1969","journal-title":"Arch Pathol"},{"key":"2024092806375513300_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-4804(76)90075-5","article-title":"A unifying pathogenetic mechanism in the etiology of intraperitoneal adhesions","volume":"20","author":"Buckman","year":"1976","journal-title":"J Surg Res"},{"key":"2024092806375513300_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000128151","article-title":"Fibrinolytic activity of the human peritoneum","volume":"12","author":"Merlo","year":"1980","journal-title":"Eur Surg Res"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800760422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/76\/4\/382\/59387951\/bjs1800760422.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/76\/4\/382\/59387951\/bjs1800760422.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T06:38:10Z","timestamp":1727505490000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/76\/4\/382\/6171885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1989,4,1]]},"published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800760422","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,4]]},"published":{"date-parts":[[1989,4,1]]}}}