{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:08Z","timestamp":1760188868267,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The risk of bleeding complications in the surgical treatment of patients with von Willebrand's disease has been evaluated. Sixty-four major surgical procedures were performed in 51 patients with various forms of von Willebrand's disease. In 18 cases, the bleeding disorder was unknown at the time of surgery, resulting in bleeding complications in 12 cases (67 per cent). Forty-five operations were carried out in patients in whom the diagnosis of von Willebrand's disease was known at the time of surgery. In these patients, the following haemostatic preparations were given: factor concentrate, fresh plasma, tranexamic acid and desmopressin. Haemostatic complications occurred in three of these operations (6\u00b77 per cent); all were managed easily. No mortality was observed. It is concluded that patients with von Willebrand's disease do not carry an increased operative risk if appropriate precautions are taken.<\/jats:p>","DOI":"10.1002\/bjs.1800760428","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:52:35Z","timestamp":1172926355000},"page":"398-400","source":"Crossref","is-referenced-by-count":11,"title":["Surgery in patients with von Willebrand's disease"],"prefix":"10.1093","volume":"76","author":[{"given":"M","family":"Blomb\u00e4ck","sequence":"first","affiliation":[{"name":"Departments of Clinical Chemistry and Blood Coagulation, Medicine and Surgery, Karolinska Hospital , S-104 01 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Johansson","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Blood Coagulation, Medicine and Surgery, Karolinska Hospital , S-104 01 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Johnsson","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Blood Coagulation, Medicine and Surgery, Karolinska Hospital , S-104 01 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Swedenborg","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Blood Coagulation, Medicine and Surgery, Karolinska Hospital , S-104 01 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Wab\u00f6","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Blood Coagulation, Medicine and Surgery, Karolinska Hospital , S-104 01 Stockholm,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"2024092806432340200_bib1","first-page":"87","article-title":"Heredit\u00e4r pseudohemofili","volume":"67","author":"von Willebrand","year":"1926","journal-title":"Finska L\u00e4kar-s\u00e4llskapets Handlingar (Helsinki)"},{"key":"2024092806432340200_bib2","first-page":"203","volume-title":"Progress in hemostasis and thrombosis","author":"Zimmerman","year":"1982"},{"key":"2024092806432340200_bib3","first-page":"411","article-title":"Heterogenous abnormalities in the multimeric structure, anti-genic properties, and plasma-platelet content of factor VIII\/von Willebrand factor in subtypes of classic (type I) and variant (type IIA) von Willebrand's disease","volume":"101","author":"Weiss","year":"1983","journal-title":"J Lab Clin Med"},{"key":"2024092806432340200_bib4","first-page":"41","volume-title":"Biological and Clinical Advances","author":"Meyer","year":"1986"},{"key":"2024092806432340200_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1182\/blood.V47.5.841.841","article-title":"The pH dependence of quantitative ristocetin-induced platelet aggregation: theoretical and practical implications\u2014a new device for maintenance of platelet-rich plasma pH","volume":"47","author":"Coller","year":"1976","journal-title":"Blood"},{"key":"2024092806432340200_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365517209102748","article-title":"Electroimmunoassay","volume":"29","author":"Laurell","year":"1972","journal-title":"Scand J Clin Lab Invest"},{"key":"2024092806432340200_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0308-2261(21)00379-9","article-title":"von Willebrand's disease","volume":"12","author":"Zimmerman","year":"1983","journal-title":"Clin Haematol"},{"key":"2024092806432340200_bib8","first-page":"1","article-title":"von Willebrand's disease in Sweden","volume":"238","author":"Silwer","year":"1973","journal-title":"Acta Pediatr Scand"},{"key":"2024092806432340200_bib9","first-page":"17","article-title":"Reoperation for postoperative haemorrhagic complications","volume":"151","author":"Bergqvist","year":"1985","journal-title":"Acta Chir Scand"},{"key":"2024092806432340200_bib10","first-page":"1","article-title":"Hemophilia in Sweden. 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