{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:40:08Z","timestamp":1790502008434,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000951","name":"Anti-Cancer Council of Victoria","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000951","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A series of 908 cases of colonic carcinoma has been analysed to elucidate reasons for the poor prognosis in obstructing colonic cancer. Complete obstruction was present in 148 cases (16\u00b73 per cent), 280 cases (30\u00b78 per cent) had partial obstruction and 480 (52\u00b78 per cent) presented without obstruction. There were fewer Dukes' A tumours in those with complete obstruction (P &amp;lt;0\u00b7005) and greater numbers of advanced tumours (P &amp;lt;0\u00b70005) compared with those without obstruction. This is reflected in a lower curative resection rate of 50\u00b77 per cent in those with obstruction compared with 70\u00b76 per cent in those without obstruction (P &amp;lt;0\u00b7001). However, after curative resection there was no significant difference in the distribution of tumour stage. Patients with complete obstruction showed a higher incidence of recurrence (P &amp;lt;0\u00b701) after curative resection, consequent to an increased incidence of local recurrence (P &amp;lt;0\u00b702). Five-year cancer-specific survival for the total series was decreased from 59\u00b71 per cent in patients without obstruction to 31\u00b78 per cent in those with complete obstruction (P &amp;lt;0\u00b7001). After curative resection there was also a significant reduction in survival (P &amp;lt;0\u00b7001). It is concluded that completely obstructing colonic cancers are more aggressive than other colonic cancers.<\/jats:p>","DOI":"10.1002\/bjs.1800760932","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:34:11Z","timestamp":1172928851000},"page":"965-969","source":"Crossref","is-referenced-by-count":131,"title":["Obstructing carcinomas of the colon"],"prefix":"10.1093","volume":"76","author":[{"given":"J W","family":"Serpell","sequence":"first","affiliation":[{"name":"Department of Surgery, Monash University, Alfred Hospital , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F T","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Surgery, Monash University, Alfred Hospital , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Katrivessis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Monash University, Alfred Hospital , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E S R","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Monash University, Alfred Hospital , Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"2024092807495583900_bib1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/0002-9610(82)90050-2","article-title":"Prognosis in patients with obstructing colorectal carcinoma","volume":"143","author":"Ohman","year":"1982","journal-title":"Am J Surg"},{"key":"2024092807495583900_bib2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/bjs.1800641015","article-title":"The treatment of colonic carcinoma presenting with intestinal obstruction","volume":"64","author":"Irvin","year":"1977","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02555634","article-title":"Survival in acute obstructing colorectal carcinoma","volume":"27","author":"Umpleby","year":"1984","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF02586665","article-title":"Obstructive colonic cancer","volume":"21","author":"Gennaro","year":"1978","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/bjs.1800720417","article-title":"Malignant large bowel obstruction","volume":"72","author":"Phillips","year":"1985","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02556917","article-title":"One-stage operation for obstructing carcinomas of the left colon and rectum","volume":"30","author":"Feng","year":"1987","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/bjs.1800530708","article-title":"Mortality of acute large bowel obstruction","volume":"53","author":"Hughes","year":"1966","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0002-9610(76)90417-7","article-title":"Mortality and prognosis of obstructing carcinoma of the large bowel","volume":"131","author":"Dutton","year":"1976","journal-title":"Am J Surg"},{"key":"2024092807495583900_bib9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/0002-9610(74)90302-X","article-title":"Management of severe obstruction of the large bowel due to malignant disease","volume":"129","author":"Welch","year":"1974","journal-title":"Am J Surg"},{"key":"2024092807495583900_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0002-9610(71)90137-1","article-title":"Correlation of the prognosis of obstructing colorectal carcinoma with clinical and pathological variables","volume":"121","author":"Ragland","year":"1971","journal-title":"Am J Surg"},{"key":"2024092807495583900_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02586464","article-title":"Evolution of surgery for large intestinal obstruction","volume":"21","author":"Wangensteen","year":"1978","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.1700350303","article-title":"The classification of cancer of the rectum","volume":"35","author":"Dukes","year":"1932","journal-title":"J Path Bact"},{"key":"2024092807495583900_bib13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/bjs.1800630513","article-title":"The prognosis after surgical treatment for carcinoma of the rectum","volume":"63","author":"Whittaker","year":"1976","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5694\/j.1326-5377.1976.tb130256.x","article-title":"Long-term study of large-bowel cancer","volume":"2","author":"Hughes","year":"1976","journal-title":"Med J Aust"},{"key":"2024092807495583900_bib15","volume-title":"Statistical Package for the Social Sciences","author":"Nie","year":"1975","edition":"2nd"},{"key":"2024092807495583900_bib16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Ass"},{"key":"2024092807495583900_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/biomet\/52.1-2.203","article-title":"A generalised Wilcoxon test for comparing arbitrarily singly censored samples","volume":"52","author":"Gehan","year":"1965","journal-title":"Biometrika"},{"key":"2024092807495583900_bib18","first-page":"883","article-title":"Duration of symptoms and prognosis of carcinoma of the colon and rectum","volume":"144","author":"Irvin","year":"1977","journal-title":"Surg Gynecol Obstet"},{"key":"2024092807495583900_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02554227","article-title":"The association of synchronous neoplasms with occluding colorectal cancer","volume":"28","author":"Bat","year":"1985","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib20","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00000658-198312000-00013","article-title":"The prognostic significance of tumour location and bowel obstruction in Dukes' B and C colorectal cancer","volume":"198","author":"Wolmark","year":"1984","journal-title":"Ann Surg"},{"key":"2024092807495583900_bib21","first-page":"541","article-title":"Treatment of obstructing cancer of the colon and rectum","volume":"141","author":"Clark","year":"1975","journal-title":"Surg Gynecol Obstet"},{"key":"2024092807495583900_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/bmj.2.6189.515","article-title":"Large bowel obstruction caused by cancer: a prospective study","volume":"2","author":"Fielding","year":"1979","journal-title":"Br Med J"},{"key":"2024092807495583900_bib23","first-page":"219","article-title":"Mortality in patients with obstructing colorectal cancer","volume":"68","author":"Waldron","year":"1986","journal-title":"Ann R Coll Surg"},{"key":"2024092807495583900_bib24","first-page":"600","article-title":"Carcinoma of the colon: a clinical correlation between presenting symptoms and survival","volume":"46","author":"Raftery","year":"1980","journal-title":"Ann Surg"},{"key":"2024092807495583900_bib25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/BF02604299","article-title":"Proximal faecal diversion: review of ten years experience","volume":"24","author":"Warra","year":"1981","journal-title":"Dis Colon Rectum"},{"key":"2024092807495583900_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1001\/archsurg.1982.01380270033007","article-title":"Complications of emergency stoma formation","volume":"117","author":"Stothert","year":"1982","journal-title":"Arch Surg"},{"key":"2024092807495583900_bib27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/bjs.1800720911","article-title":"Intraoperative colonic irrigation in the management of left sided large bowel emergencies","volume":"72","author":"Koruth","year":"1985","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/bjs.1800730320","article-title":"Emergency presentation and mortality from colorectal cancer in the elderly","volume":"73","author":"Waldron","year":"1986","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1200\/JCO.1985.3.3.379","article-title":"Obstructive and perforative colonic carcinoma: patterns of failure","volume":"3","author":"Willett","year":"1985","journal-title":"J Clin Oncol"},{"key":"2024092807495583900_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/bjs.1800610105","article-title":"Survival after primary and after staged resection for large bowel obstruction caused by cancer","volume":"61","author":"Fielding","year":"1974","journal-title":"Br J Surg"},{"key":"2024092807495583900_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02562483","article-title":"One-stage subtotal colectomy with anastomosis for obstructing carcinoma of the left colon","volume":"26","author":"Deutsch","year":"1983","journal-title":"Dis Colon Rectum"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800760932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/76\/9\/965\/59389555\/bjs1800760932.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/76\/9\/965\/59389555\/bjs1800760932.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T07:50:11Z","timestamp":1727509811000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/76\/9\/965\/6171496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9,1]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1989,9,1]]},"published-print":{"date-parts":[[1989,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800760932","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,9]]},"published":{"date-parts":[[1989,9,1]]}}}