{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:16Z","timestamp":1761058636636},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1989,10,1]],"date-time":"1989-10-01T00:00:00Z","timestamp":623203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A total of 519 patients presenting with carcinoma of the caecum in the Plymouth Health District between 1975 and 1987 were reviewed. The clinical course was determined in relation to patients with and without a history of previous appendicectomy. There was no difference in the incidence of previous appendicectomy between patients with carcinoma of the caecum and an age and sex matched control group. The presence of synchronous carcinomas and\/or adenomas was unrelated to previous appendicectomy. Ten patients presented with appendicitis and 11 with a mucocele of the appendix as the first sign of carcinoma of the caecum. Previous appendicectomy was associated with a higher incidence of local fixity, invasion of the abdominal wall, metastatic spread and poor differentiation. These differences were reflected in a significantly lower resection rate for carcinomas in patients who had previously undergone appendicectomy. The survival of patients who had previously had appendicectomy was significantly reduced. Four independent prognostic factors for survival were identified using multivariate discriminant analysis. These were Dukes' classification, local invasion, tumour differentiation and previous appendicectomy. Local recurrence was more common in patients who had previously had appendicectomy and was often in the old appendicectomy wound itself. Appendicectomy does not increase the risk of carcinogenesis in the caecum. In this study a history of appendicectomy was an independent risk factor for survival and significantly worsened the prognosis for patients who subsequently developed carcinoma of the caecum.<\/jats:p>","DOI":"10.1002\/bjs.1800761022","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T11:07:46Z","timestamp":1172920066000},"page":"1049-1053","source":"Crossref","is-referenced-by-count":17,"title":["Appendicectomy and carcinoma of the caecum"],"prefix":"10.1093","volume":"76","author":[{"given":"C P","family":"Armstrong","sequence":"first","affiliation":[{"name":"Derriford Hospital , Plymouth, Devon,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Derriford Hospital , Plymouth, Devon,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Hinchley","sequence":"additional","affiliation":[{"name":"Derriford Hospital , Plymouth, Devon,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Prothero","sequence":"additional","affiliation":[{"name":"Derriford Hospital , Plymouth, Devon,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J M","family":"Brodribb","sequence":"additional","affiliation":[{"name":"Derriford Hospital , Plymouth, Devon,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,10,1]]},"reference":[{"key":"2024092806382322800_bib1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/1097-0142(19810301)47:5+<1170::AID-CNCR2820471319>3.0.CO;2-S","article-title":"Colorectal cancer\u2014prevention and detection","volume":"47","author":"Lefall","year":"1981","journal-title":"Cancer"},{"key":"2024092806382322800_bib2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0002-9610(79)90124-7","article-title":"Increasing 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