{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:21:11Z","timestamp":1791393671137,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Highly selective vagotomy for duodenal ulcer was performed on 307 patients between 1973 and 1983 without operative mortality. Of these, 283 (92\u00b72per cent) were followed up prospectively for a minimum of 5 years. Recurrent ulcer was diagnosed in 49 (17\u00b73per cent). The recurrent ulcer rate increased from 13\u00b72per cent at 5 years to 19\u00b74per cent at 12 years. Age, length of history, previous haemorrhage or perforation and preoperative acid output were not associated with increased risk of recurrent ulceration. The risk in men and smokers was higher but not significantly so. The recurrence rate for individual surgeons varied from 5\u00b73 to 25\u00b76 per cent. Failure of healing with H2-receptor antagonists was not associated with a higher recurrent ulcer rate. Patients with a strong family history (more than one first degree relative affected) had a significantly higher recurrence rate (33\u00b72per cent at 10 years) than those without (13\u00b75per cent at 10 years). Of the 49 recurrent ulcer patients, 30 (61\u00b72per cent) required either an operation or regular H2-receptor antagonists. Of the 250 patients (81\u00b74per cent) available in 1988 for review of symptoms 5\u201315 years after operation, 5\u00b74per cent had dumping, 8\u00b79per cent epigastric pain, and 11\u00b78per cent heartburn every day or most days. H2-receptor antagonists were required by 10\u00b77 per cent of patients on a frequent or regular basis. Of 239 patients who answered the question, 218 (91\u00b72per cent) felt that their symptoms had been cured or greatly improved and 203 (84\u00b79) considered the operation a success. Despite the high recurrence rate, the operation was successful in controlling ulcer symptoms in around 90 per cent of patients and produced postvagotomy symptoms - none severe - in around 5 per cent of patients.<\/jats:p>","DOI":"10.1002\/bjs.1800770124","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:30:25Z","timestamp":1172928625000},"page":"65-69","source":"Crossref","is-referenced-by-count":23,"title":["Highly selective vagotomy 5\u201315 years on"],"prefix":"10.1093","volume":"77","author":[{"given":"I M C","family":"MacIntyre","sequence":"first","affiliation":[{"name":"Surgical Review Office and Castro-Intestinal Unit, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Millar","sequence":"additional","affiliation":[{"name":"Surgical Review Office and Castro-Intestinal Unit, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Smith","sequence":"additional","affiliation":[{"name":"Surgical Review Office and Castro-Intestinal Unit, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W P","family":"Small","sequence":"additional","affiliation":[{"name":"Surgical Review Office and Castro-Intestinal Unit, Western General Hospital , Edinburgh,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"2024092807415334300_bib1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/bjs.1800741132","article-title":"Prospective 14\u201318 year follow-up study after parietal cell vagotomy","volume":"74","author":"Hoffman","year":"1987","journal-title":"Br J Surg"},{"key":"2024092807415334300_bib2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1136\/bmj.296.6628.1031","article-title":"Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists","volume":"296","author":"Primrose","year":"1988","journal-title":"Br Med J"},{"key":"2024092807415334300_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000658-197409000-00004","article-title":"Clinical results of parietal cell vagotomy (highly selective vagotomy) 2\u20134 years after operation","volume":"180","author":"Amdrup","year":"1974","journal-title":"Ann Surg"},{"key":"2024092807415334300_bib4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/00000658-198608000-00002","article-title":"Proximal gastric vagotomy. 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