{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:46:42Z","timestamp":1756993602639},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Between 1 January 1980 and 31 July 1988, 62 patients with chronic lymphocytic leukaemia (CLL) or malignant non-Hodgkin's lymphoma (NHL) were splenectomized for splenomegaly and presumed hypersplenism. All patients except one had splenomegaly (mean(s.d.) weight 1585 (872) g, range 150\u20134300 g) and 34 had massive splenomegaly (&amp;gt; 1500 g). Forty-nine patients had platelet counts &amp;lt; 100 \u00d7 109\/l and 16 patients had anaemia with haemoglobin levels &amp;lt; 10 g\/dl. White cell counts were &amp;lt; 3\u00d7109\/l in six NHL patients. Fifteen patients had bicytopenia, and three NHL patients had tricytopenia. The selected group of 62 patients underwent splenectomy largely because of failure to respond to medical therapy (39 patients) or inability to tolerate or start adequate chemotherapy because of very low blood counts (11 patients). There was one postoperative death, and a 29 per cent morbidity rate. The response rate was 89 per cent in the first month after splenectomy and 39 patients (63 per cent) had a continuing complete response with a median follow-up of 26 months (range 3\u201396 months). Twelve patients (10 with CLL) received no further therapy after splenectomy. Seven patients failed to respond and 15 relapsed after splenectomy. These 22 patients could be distinguished on the basis of: (1) lower average preoperative platelet counts (P &amp;lt; 0\u00b7007), postoperative platelet counts (P &amp;lt; 0\u00b7001), and postoperative rise in platelets (P &amp;lt; 0\u00b7004); (2) lower average spleen weight (P &amp;lt; 0\u00b7052); (3) preoperative chemotherapy (P &amp;lt; 0\u00b7044). However preoperative and postoperative platelet counts were the only two variables selected by stepwise regression analysis (P &amp;lt; 0\u00b705 and P &amp;lt; 0\u00b701, respectively). Bone marrow failure did not preclude complete response after splenectomy. Long-term survivors emerged from the group of patients with continuing complete response. Of the seven patients who failed to respond, five died with a median survival of 4 months, and of the 15 patients who relapsed after splenectomy, 13 died, with a median survival of 6 months after relapse and 18 months after splenectomy. Thus, splenectomy may be an effective palliation for both CLL and NHL patients with splenomegaly and hypersplenism.<\/jats:p>","DOI":"10.1002\/bjs.1800770427","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:58:05Z","timestamp":1172930285000},"page":"443-449","source":"Crossref","is-referenced-by-count":39,"title":["Splenectomy for hypersplenism in chronic lymphocytic leukaemia and malignant non-Hodgkin's lymphoma"],"prefix":"10.1093","volume":"77","author":[{"given":"J R","family":"Delpero","sequence":"first","affiliation":[{"name":"Department of Surgery, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Houvenaeghel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Gastaut","sequence":"additional","affiliation":[{"name":"Department of Haematology, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Orsoni","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Blache","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Guerinel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Carcassonne","sequence":"additional","affiliation":[{"name":"Department of Haematology, Institute of Cancer (Institut J. Paoli-I. Calmettes) , 232 boulevard de Sainte Marguerite, 13272, Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"2024092807573919300_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1056\/NEJM195203272461301","article-title":"Splenectomy in leukemia and leukosarcoma","volume":"246","author":"Fisher","year":"1952","journal-title":"N Engl J Med"},{"key":"2024092807573919300_bib2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00000658-196305000-00008","article-title":"Splenectomy in the treatment of secondary hypersplenism","volume":"157","author":"Duckett","year":"1963","journal-title":"Ann Surg"},{"key":"2024092807573919300_bib3","first-page":"519","article-title":"Splenectomy in leukemia: hematologic and clinical effects on 34 patients and review of 299 published cases","volume":"26","author":"Strumia","year":"1966","journal-title":"Cancer 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