{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:19:56Z","timestamp":1761153596092},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a randomized prospective controlled trial involving 311 patients undergoing acute or elective colorectal surgery, the efficacy and safety of two different single dose and one triple dose regimen of antibiotic prophylaxis, as well as the influence of blood transfusion on postoperative infectious complications, were studied. Postoperative infectious complications occurred in a total of 59 patients (19-0 per cent). There were no major differences between the three treatment groups. Thirty-four patients (10\u00b79 per cent) developed abdominal wound infection, 17 patients (5\u00b75 per cent) intra-abdominal abscess and 16 patients (5\u00b71 per cent) anastomotic leakage. Of 202 patients (65\u00b70 per cent) requiring blood transfusion during hospitalization 57 (28\u00b72 per cent; 95 per cent confidence limits of 23\u00b736 per cent) developed infectious complications, whereas two non-transfused patients (1\u00b78per cent; 95per cent confidence limits of 0\u00b72 to 6per cent; P&amp;lt;0\u00b7001) developed infectious complications. It is concluded that one single dose of antibiotic prophylaxis in acute and elective colorectal surgery is as protective as a triple dose regimen. The development of infectious complications despite antibiotic prophylaxis is strongly related to blood transfusion.<\/jats:p>","DOI":"10.1002\/bjs.1800770514","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:56:41Z","timestamp":1172930201000},"page":"513-518","source":"Crossref","is-referenced-by-count":46,"title":["Comparison of one dose <i>versus<\/i> three doses of prophylactic antibiotics, and the influence of blood transfusion, on infectious complications in acute and elective colorectal surgery"],"prefix":"10.1093","volume":"77","author":[{"given":"L S","family":"Jensen","sequence":"first","affiliation":[{"name":"University Department of Surgical Gastroenterology, Aarhus Municipal Hospital ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Andersen","sequence":"additional","affiliation":[{"name":"University Department of Surgical Gastroenterology, Aarhus Municipal Hospital 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