{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:39:32Z","timestamp":1772800772920,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["1765-B89-08XC"],"award-info":[{"award-number":["1765-B89-08XC"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Within a prospective randomized screening study for early detection of colorectal cancer with rehydrated Hemoccult II\u00ae test, the possibility of increasing the specificity of the test by retesting patients with an initially positive Hemoccult II test was investigated. Of those offered the test 3561 (62\u00b76 per cent) returned it and it was positive in 210 cases (5\u00b79 per cent). The repeat test was performed by 184 patients and was positive in 68 (1\u00b79 per cent). All those with a positive initial test had rectosigmoidoscopy to 60 cm and a double contrast enema. A carcinoma was found in one in seven patients with a positive retest but in only one in 100 patients with a negative retest (P &amp;lt; 0\u00b7001). The specificity of the test was, therefore, increased from 95 per cent to 98 per cent and the sensitivity was unchanged. Rescreening was offered at a later date and increased numbers were available: 7147 patients returned the test and 369 (5\u00b72 per cent) were positive. The test was repeated in 360 patients and 118 (1\u00b77 per cent) were positive. A colorectal neoplasm was found in one in three of those with a positive repeat test, compared with one in seven of those with a negative repeat test. In conclusion, screening for early detection of colorectal cancer with a rehydrated Hemoccult II test may be followed by investigation of only those patients with a positive retest. Such a procedure will reduce the work-load by 60 per cent without reducing sensitivity.<\/jats:p>","DOI":"10.1002\/bjs.1800771210","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:52:09Z","timestamp":1172929929000},"page":"1349-1351","source":"Crossref","is-referenced-by-count":16,"title":["Value of retesting subjects with a positive Hemoccult\u00ae in screening for colorectal cancer"],"prefix":"10.1093","volume":"77","author":[{"given":"J","family":"Kewenter","sequence":"first","affiliation":[{"name":"Department of Surgery, Sahlgrenska Hospital , S-413 45 Goteborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Engar\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sahlgrenska Hospital , S-413 45 Goteborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sahlgrenska Hospital , S-413 45 Goteborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sahlgrenska Hospital , S-413 45 Goteborg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,12,1]]},"reference":[{"key":"2024092807583268800_bib1","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1002\/1097-0142(19800615)45:12<2959::AID-CNCR2820451212>3.0.CO;2-E","article-title":"Progress report on controlled trial of fecal occult blood testing for the detection of colorectal neoplasia","volume":"45","author":"Winawer","year":"1980","journal-title":"Cancer"},{"key":"2024092807583268800_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00365528909093096","article-title":"Repeated screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen, Denmark","volume":"24","author":"Kronborg","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"2024092807583268800_bib3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0140-6736(89)92750-5","article-title":"Randomised, controlled trial of faecal occult blood screening for colorectal cancer","volume":"i","author":"Hardcastle","year":"1989","journal-title":"Lancet"},{"key":"2024092807583268800_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0021-9681(80)90034-X","article-title":"The design of a study to assess occult-blood screening for colon cancer","volume":"33","author":"Gilbertsen","year":"1980","journal-title":"J Chronic Dis"},{"key":"2024092807583268800_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/1097-0142(19880801)62:3<645::AID-CNCR2820620333>3.0.CO;2-#","article-title":"Screening and rescreening for colorectal cancer. 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