{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:28Z","timestamp":1786977148822,"version":"build-2736575974"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Medical Research Council of the Academy of Finland, Helsinki, Finland"},{"name":"Smith Kline and French Company, Solna, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the effects of improvements in medical therapy on the incidence of, indications for and operative methods used in peptic ulcer surgery, all cases of primary peptic ulcer surgery among adults in the city of Helsinki in the years 1972, 1977, 1982 and 1987 were analysed. There was a total of 565 such cases in a population which consisted of 5\u00b72 \u00d7 105 individuals in 1972 and 4\u00b78 \u00d7 105 individuals in 1987. The introduction of H2-receptor antagonists in 1979 was associated with a fall in the annual incidence of elective duodenal ulcer operations, from 15\u00b75 to 6\u00b77 per 105 individuals, and a fall in the annual incidence of elective gastric ulcer operations, from 9\u00b74 to 3\u00b71 per 105 individuals (P &amp;lt; 0\u00b705). The decrease was greatest among males with duodenal ulcer. In contrast, the annual incidence of emergency surgery for ulcer haemorrhage and perforation (all types of ulcers) remained relatively stable, varying from 7\u00b72 to 10\u00b72 per 105 inhabitants over the observation period (n.s.). The mean age of patients undergoing elective surgery remained essentially unchanged. The mean age of patients undergoing emergency surgery increased. The decrease in the annual incidence of elective duodenal ulcer surgery occurred mainly in relation to proximal gastric vagotomy. There was a concomitant relative increase in the incidence of gastric resection. The types of operative procedures used in cases of pyloric, prepyloric and gastric ulcer remained unchanged over the years 1972 to 1987.<\/jats:p>","DOI":"10.1002\/bjs.1800780110","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T09:47:01Z","timestamp":1172915221000},"page":"28-31","source":"Crossref","is-referenced-by-count":32,"title":["Peptic ulcer surgery during the H2-receptor antagonist era: A population-based epidemiological study of ulcer surgery in Helsinki from 1972 to 1987"],"prefix":"10.1093","volume":"78","author":[{"given":"H","family":"Paimela","sequence":"first","affiliation":[{"name":"Department of Surgery, Malmi Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Tuompo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Malmi Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Per\u00e4kyl\u00e4","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maria Helsinki City Hospitals, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Saario","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"H\u00f6ckerstedt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maria Helsinki City Hospitals, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kivilaakso","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, Helsinki University Central Hospital , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"2024092809180698900_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3181\/00379727-53-14227","article-title":"Supra-diaphragmatic section of the vagus nerves in treatment of duodenal ulcer","volume":"53","author":"Dragstedt","year":"1943","journal-title":"Proc Soc Exp Biol Med"},{"key":"2024092809180698900_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0016-5085(57)80091-2","article-title":"Partial gastric vagotomy: an experimental study","volume":"32","author":"Griffith","year":"1957","journal-title":"Gastroenterology"},{"key":"2024092809180698900_bib3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0016-5085(19)33704-7","article-title":"Selective vagotomy of the parietal cell mass preserving innervation of the undrained antrum. A preliminary report of results in patients with duodenal ulcer","volume":"59","author":"Amdrup","year":"1970","journal-title":"Gastroenterology"},{"key":"2024092809180698900_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/bjs.1800570414","article-title":"Highly selective vagotomy without a drainage procedure in the treatment of duodenal ulcer","volume":"57","author":"Johnston","year":"1970","journal-title":"Br J Surg"},{"key":"2024092809180698900_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archsurg.1980.01380020004002","article-title":"The declining role of the surgeon in the treatment of acid-peptic diseases","volume":"115","author":"Penn","year":"1980","journal-title":"Arch Surg"},{"key":"2024092809180698900_bib6","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0140-6736(81)92471-5","article-title":"Surgical treatment of peptic ulcer in the United States. Trends before and after the introduction of cimetidine","volume":"i","author":"Fineberg","year":"1981","journal-title":"Lancet"},{"key":"2024092809180698900_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1001\/jama.1977.03270370059023","article-title":"Decline in duodenal ulcer surgery","volume":"237","author":"Smith","year":"1977","journal-title":"JAMA"},{"key":"2024092809180698900_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0300-5089(21)00614-3","article-title":"Epidemiology of peptic ulcer disease","volume":"13","author":"Kurata","year":"1984","journal-title":"Clin Gastroenterol"},{"key":"2024092809180698900_bib9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/0016-5085(88)90240-5","article-title":"Trends in peptic ulcer surgery","volume":"94","author":"Gustavsson","year":"1988","journal-title":"Gastroenterology"},{"key":"2024092809180698900_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/00365528809096296","article-title":"Peptic ulcer disease - Trends in surgical management in Sweden","volume":"23","author":"Gustavsson","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"2024092809180698900_bib11","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1136\/bmj.299.6708.1131","article-title":"Incidence of peptic ulcer disease in Gothenburg, 1985","volume":"299","author":"Sch\u00f6\u00f6n","year":"1989","journal-title":"Br Med J"},{"key":"2024092809180698900_bib12","volume-title":"Frontiers of Gastrointestinal Research","author":"Siurala","year":"1980"},{"key":"2024092809180698900_bib13","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-349-03188-7","volume-title":"Clinical Tests of Gastric Secretion","author":"Baron","year":"1978"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800780110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/78\/1\/28\/59393912\/bjs1800780110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/78\/1\/28\/59393912\/bjs1800780110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T05:18:21Z","timestamp":1727500701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/78\/1\/28\/6173604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1991,1,1]]},"published-print":{"date-parts":[[1991,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800780110","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,1]]},"published":{"date-parts":[[1991,1,1]]}}}