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We have investigated the influence of methylprednisolone (2\u00b75 or 10\u00b70 mg kg\u22121 day\u22121) given from 2 days before operation onwards, on 3-day-old and 7-day-old ileal and colonic anastomoses in rats. Anastomotic abscesses occurred more frequently in the ileum, but not in the colon, after steroid medication. However, methylprednisolone did not lower anastomotic bursting pressures in either of the bowel segments. Comparison of the hydroxyproline content of the anastomotic segment yielded no significant difference between control and methylprednisolone groups in either small or large bowel. Thus, healing of experimental colonic anastomoses remains unaffected by short-term administration of this corticosteroid.<\/jats:p>","DOI":"10.1002\/bjs.1800780118","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T14:47:01Z","timestamp":1172933221000},"page":"54-56","source":"Crossref","is-referenced-by-count":20,"title":["Influence of methylprednisolone on the healing of intestinal anastomoses in rats"],"prefix":"10.1093","volume":"78","author":[{"given":"W J B","family":"Mastboom","sequence":"first","affiliation":[{"name":"Department of General Surgery, St. Radboud University Hospital , Nijmegen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Radboud University Hospital , Nijmegen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"de Man","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Radboud University Hospital , Nijmegen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H H M","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Radboud University Hospital , Nijmegen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"2024092808591863500_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0140-6736(78)92660-0","article-title":"Surgeon-related variables and the clinical trial","volume":"ii","author":"Fielding","year":"1978","journal-title":"Lancet"},{"key":"2024092808591863500_bib2","first-page":"184","volume-title":"Wound Healing and Wound Infection","author":"Schrock","year":"1980"},{"key":"2024092808591863500_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00000658-197305000-00002","article-title":"Factors contributing to leakage of colonic anastomoses","volume":"177","author":"Schrock","year":"1973","journal-title":"Ann Surg"},{"key":"2024092808591863500_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/bjs.1800551109","article-title":"The effect of systemic steroids on ileorectal anastomosis in ulcerative colitis","volume":"55","author":"Price","year":"1968","journal-title":"Br J Surg"},{"key":"2024092808591863500_bib5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00000658-196803000-00004","article-title":"Effects of cortisone and vitamin A on wound healing","volume":"167","author":"Ehrlich","year":"1968","journal-title":"Ann Surg"},{"key":"2024092808591863500_bib6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/archderm.1984.01650430064012","article-title":"Anti-inflammatory adrenal steroids that neither inhibit skin collagen synthesis nor cause dermal atrophy","volume":"120","author":"DiPetrillo","year":"1984","journal-title":"Arch Dermatol"},{"key":"2024092808591863500_bib7","first-page":"815","article-title":"Action of carnosine and \u03b2-alanine on wound healing","volume":"100","author":"Nagai","year":"1986","journal-title":"Surgery"},{"key":"2024092808591863500_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bjs.1800700302","article-title":"Current concepts in soft connective tissue wound healing","volume":"70","author":"Forrest","year":"1983","journal-title":"Br J Surg"},{"key":"2024092808591863500_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/oxfordjournals.bmb.a072065","article-title":"Recovery and tissue repair","volume":"41","author":"Smith","year":"1985","journal-title":"Br Med Bull"},{"key":"2024092808591863500_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-4804(81)90045-7","article-title":"Healing of incisional wounds in stomach and duodenum: the effect of long term cortisol treatment","volume":"31","author":"Gottrup","year":"1981","journal-title":"J Surg Res"},{"key":"2024092808591863500_bib11","first-page":"546","article-title":"Effects of corticosteroid on the healing bowel anastomosis","volume":"50","author":"Aszodi","year":"1984","journal-title":"Am Surg"},{"key":"2024092808591863500_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archsurg.1988.01400260118015","article-title":"Fibrin sealant in high-risk colonic anastomoses","volume":"123","author":"Houston","year":"1988","journal-title":"Arch Surg"},{"key":"2024092808591863500_bib13","first-page":"307","article-title":"The effect of methylprednisolone and vitamin A on wound healing. 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