{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:08:47Z","timestamp":1791230927308,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peritoneal adhesions cause much long-term postoperative morbidity. This study evaluates the efficacy of polyethylene glycol (PEG) 4000 in reducing adhesion reformation after lysis. Adhesions were induced, by abrasion, in 111 Sprague-Dawley rats at a first laparotomy. At a second operation, 10 days later, these adhesions were graded and lysed, after which the animals received one of the following solutions intra-peritoneally: 5 per cent PEG 4000 (n = 21), 25 per cent PEG 4000 (n = 23), 32 per cent dextran 70 (n = 22) or isotonic saline (n = 25), or were left as an untreated control group (n = 20). When the reformed adhesions were graded after a further 10 days 5 per cent PEG 4000 was found to be the only solution that inhibited adhesion reformation. The adhesions that reformed in the other four test groups were significantly worse than when they were first graded (P \u22660\u00b7033 for all groups). Therefore 5 per cent PEG 4000 may be useful in clinical practice for the reduction of adhesion formation after lysis.<\/jats:p>","DOI":"10.1002\/bjs.1800780414","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T15:40:02Z","timestamp":1172936402000},"page":"427-429","source":"Crossref","is-referenced-by-count":31,"title":["Peritoneal adhesion formation after lysis: Inhibition by polyethylene glycol 4000"],"prefix":"10.1093","volume":"78","author":[{"given":"D","family":"O'Sullivan","sequence":"first","affiliation":[{"name":"University Department of Surgery, Regional Hospital , Cork,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"O'Riordain","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Regional Hospital , Cork,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"O'Connell","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Regional Hospital , Cork,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dineen","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Regional Hospital , Cork,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Brady","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Regional Hospital , Cork,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"2024092809443119600_bib1","first-page":"60","article-title":"Intestinal obstruction from adhesions\u2014how big is the problem?","volume":"72","author":"Menzies","year":"1990","journal-title":"Ann R Coll Surg Engl"},{"key":"2024092809443119600_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/archsurg.1977.01370040157024","article-title":"Bowel obstruction and the long tube stent","volume":"112","author":"Brightwell","year":"1977","journal-title":"Arch Surg"},{"key":"2024092809443119600_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/bjs.1800670118","article-title":"Absorbable haemostatic materials and intra-peritoneal adhesion formation","volume":"67","author":"Raftery","year":"1980","journal-title":"Br J Surg"},{"key":"2024092809443119600_bib4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0002-9378(82)90018-7","article-title":"Prevention of postoperative adhesions: an animal study comparing barrier methods with dextran 70","volume":"143","author":"Soules","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"2024092809443119600_bib5","first-page":"497","article-title":"The cause and prevention of post-operative intra-peritoneal adhesions","volume":"133","author":"Ellis","year":"1971","journal-title":"Surg Gynecol Obstet"},{"key":"2024092809443119600_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0002-9378(84)90711-7","article-title":"High-molecular weight dextran in human infertility surgery","volume":"148","author":"Rosenberg","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"2024092809443119600_bib7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0015-0282(16)44782-5","article-title":"Effect of thirty two per cent dextran 70 on peritoneal adhesion formation and reformation after lysis","volume":"33","author":"Holtz","year":"1980","journal-title":"Fertil Steril"},{"key":"2024092809443119600_bib8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archsurg.1980.01380060074022","article-title":"Peritoneal adhesions: prevention with the use of hydrophilic polymer coatings","volume":"115","author":"Goldberg","year":"1980","journal-title":"Arch Surg"},{"key":"2024092809443119600_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0015-0282(16)44588-7","article-title":"Adjuvants in tubal surgery","volume":"33","author":"Pfeffer","year":"1980","journal-title":"Fertil Steril"},{"key":"2024092809443119600_bib10","first-page":"336","article-title":"High molecular weight dextran: effect on adhesion formation and peritonitis in rats","volume":"94","author":"Fabri","year":"1983","journal-title":"Surgery"},{"key":"2024092809443119600_bib11","first-page":"173","article-title":"Prevention of post-operative tubal adhesions. 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