{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:56:39Z","timestamp":1780516599223,"version":"3.54.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A retrospective study was undertaken of 41 patients diagnosed as having suffered spontaneous liver rupture over a 4-year period to identify the clinical features, treatment and outcome of this complication in an area in which hepatocellular carcinoma is endemic. Two patients were excluded with a revised diagnosis of haemorrhagic malignant ascites. Of the remaining 39 patients, 37 bled from ruptured hepatocellular carcinoma, one from peliosis hepatis and multiple liver cell adenomas, and one from a malignant hepatic epithelioid haemangioendothelioma. Analysis showed that 59 per cent of patients were in shock on admission and that all but two of the 37 patients with ruptured hepatocellular carcinoma were men with cirrhosis. The association with cirrhosis was significantly higher than in a series of 45 patients with hepatocellular carcinoma undergoing elective resection during the same period (P&amp;lt;0\u00b705). Treatment consisted of supportive care only in two patients, angiographic embolization in four, emergency liver resection in 11 of whom six died, hepatic artery ligation in 12 of whom eight died, and suture and\/or packing in eight of whom six died. One patient died at laparotomy and in another patient bleeding was successfully arrested by intratumoural injection of absolute alcohol. Because of the high operative mortality of emergency surgery in these poor risk patients, prospective evaluation of emergency angiographic embolization is required.<\/jats:p>","DOI":"10.1002\/bjs.1800780424","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T15:40:02Z","timestamp":1172936402000},"page":"463-466","source":"Crossref","is-referenced-by-count":53,"title":["Management of bleeding liver tumours in Hong Kong"],"prefix":"10.1093","volume":"78","author":[{"given":"G A","family":"Dewar","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K W","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Y","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K C","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1991,4,1]]},"reference":[{"key":"2024092809410140500_bib1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/bmj.2.6047.1278-a","article-title":"Leading article: Spontaneous rupture of the liver","volume":"2","year":"1976","journal-title":"Br Med J"},{"key":"2024092809410140500_bib2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00004836-198804000-00025","article-title":"Acute haemoperitoneum from rupture of a hepatocellular carcinoma","volume":"10","author":"Clarkston","year":"1988","journal-title":"J Clin Gastroenterol"},{"key":"2024092809410140500_bib3","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/bmj.4.5784.408","article-title":"Diagnosis of primary cancer of the liver","volume":"4","author":"Kew","year":"1971","journal-title":"Br Med J"},{"key":"2024092809410140500_bib4","volume-title":"Cancer incidence in five continents","author":"Waterhouse","year":"1977"},{"key":"2024092809410140500_bib5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7326\/0003-4819-81-5-610","article-title":"Peliosis hepatis associated with androgenic-anabolic steroid therapy. 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