{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:27:54Z","timestamp":1759177674668},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Radiation detectors may allow the intraoperative localization of small cancer deposits following administration of radiolabelled tumour-associated antibodies. This technique was evaluated in 16 patients with colorectal tumours (14 cancers, one adenoma, one lipoma) with the 111In-labelled monoclonal antibody (MAb) ICR2 which recognizes the tumour-associated epithelial membrane antigen (EMA). At operation counting was carried out (3 \u00d7 20 s per site) using a hand-held radiation probe over the primary lesions and any palpable lymph nodes in the mesocolon. The tumour to normal colon (T\/NC) ratio of counts recorded at operation was more than 1\u00b75:1 in eight of the 14 patients with cancer (mean(s.d.), 1\u00b754(0\u00b741):1) and 0\u00b791:1 and 1\u00b706:1 respectively in the two patients with benign tumours. Node to normal colon ratios were higher in lymph nodes containing metastases. The uptake of radiolabelled antibody (T\/NC ratio) was higher in EMA-expressing cancers than in those not expressing the target antigen (mean(s.d.), 2\u00b745(0\u00b765):1 versus 1\u00b740(0\u00b720):1, P = 0\u00b7019). An abdominal tumour model was also developed. Radioactively filled containers of 0\u00b75\u201310 ml representing tumour deposits were suspended in a tank of 111In solution representing the background activity found in normal tissues. The ratio of radioactivity in the \u2018tumour\u2019 to that of background varied from 2:1 to 8:1. The \u2018tumour\u2019 was considered to be detectable if the mean counts recorded over the \u2018tumour\u2019 exceeded the mean of counts recorded over background by three standard deviations. At a ratio of 2:1 only \u2018tumours\u2019 greater than 5 ml could be detected with a sodium iodide probe and those over 10 ml could be detected with a cadmium telluride (CdTe) probe. At a ratio of 8:1, \u2018tumours\u2019 of 0\u00b75 ml could be detected with either probe. At all ratios and counting periods the Nal probe was more sensitive than the CdTe.<\/jats:p>","DOI":"10.1002\/bjs.1800780610","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:05:15Z","timestamp":1172937915000},"page":"664-670","source":"Crossref","is-referenced-by-count":13,"title":["Intraoperative localization of colorectal cancers using radiolabelled monoclonal antibodies"],"prefix":"10.1093","volume":"78","author":[{"given":"B R","family":"Davidson","sequence":"first","affiliation":[{"name":"Department of Surgery, University College and Middlesex School of Medicine, University College Hospital , London,","place":["UK"]},{"name":"Department of Physics and Bioengineering, University College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Waddington","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College and Middlesex School of Medicine, University College Hospital , London,","place":["UK"]},{"name":"Department of Physics and Bioengineering, University College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College and Middlesex School of Medicine, University College Hospital , London,","place":["UK"]},{"name":"Department of Physics and Bioengineering, University College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Boulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, University College and Middlesex School of Medicine, University College Hospital , London,","place":["UK"]},{"name":"Department of Physics and Bioengineering, University College Hospital , 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