{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:38:03Z","timestamp":1759847883608},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1991,9,1]],"date-time":"1991-09-01T00:00:00Z","timestamp":683683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pulmonary microvasculature was examined in two experimental models of acute pancreatitis by scanning electron microscopy of microvascular corrosion casts. Haemorrhagic pancreatitis was induced in eight male Sprague\u2014Dawley rats using an intraductal injection of 5 per cent sodium taurocholate. Oedematous pancreatitis was induced in seven male Spague\u2014Dawley rats using an intravenous infusion of supramaximal doses of caerulein (5 m\u0308g\/kg per hour). The pulmonary vessels were cast using a polymer resin and the cast studied by scanning electron microscopy at 3 and 12 h in those with haemorrhagic and at 1 and 4 h in those with oedematous pancreatitis. Vascular abnormalities were present in both models at the initial study time with abruptly terminating vessels being more prominent in the caerulein model. At the later times, however, the abnormalities in the sodium taurocholate model were much more severe, with a substantial loss of vascular density, tortuosity and abrupt terminations of those vessels present. Micro-vascular abnormalities may be responsible for some of the pulmonary changes seen in oedematous and haemorrhagic pancreatitis.<\/jats:p>","DOI":"10.1002\/bjs.1800780911","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:17:48Z","timestamp":1172938668000},"page":"1064-1067","source":"Crossref","is-referenced-by-count":7,"title":["Pulmonary microvasculature in experimental acute haemorrhagic and oedematous pancreatitis"],"prefix":"10.1093","volume":"78","author":[{"given":"D M","family":"Kelly","sequence":"first","affiliation":[{"name":"Department of Surgery, Mater Misericordiae Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P","family":"McEntee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mater Misericordiae Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K F","family":"McGeeney","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, University College , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mater Misericordiae Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,9,1]]},"reference":[{"key":"2024092809431984200_bib1","first-page":"324","article-title":"Sequential haemodynamic and oxygen transport abnormalities in patients with acute pancreatitis","volume":"95","author":"Cobo","year":"1984","journal-title":"Surgery"},{"key":"2024092809431984200_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0002-9610(74)90040-3","article-title":"Adult respiratory distress syndrome in association with acute pancreatitis","volume":"127","author":"Hayes","year":"1974","journal-title":"Am J Surg"},{"key":"2024092809431984200_bib3","first-page":"236","article-title":"Extrapancreatic organ impairment in haemorrhagic pancreatitis is associated with systemic microvascular injury","volume":"158","author":"Kelly","year":"1989","journal-title":"Ir J Med Sci"},{"key":"2024092809431984200_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/00365528009181494","article-title":"Experimental pancreatitis in the rat: ultrastructure of sodium taurocholate induced pancreatic lesions","volume":"15","author":"Aho","year":"1980","journal-title":"Scand J Gastroenterol"},{"key":"2024092809431984200_bib5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/bjs.1800760830","article-title":"Three dimensional morphological study of the pancreatic microvasculature in caerulein induced experimental pancreatitis","volume":"76","author":"McEntee","year":"1989","journal-title":"Br J Surg"},{"key":"2024092809431984200_bib6","first-page":"35","article-title":"Ultrastructural and biochemical changes after marked caerulein stimulation of the exocrine pancreas in the dog","volume":"62","author":"Tardini","year":"1971","journal-title":"Am J Pathol"},{"key":"2024092809431984200_bib7","first-page":"817","article-title":"Study of the rat lung alveoli using corrosion casting and freeze fracture methods coupled with digital image analysis","volume":"1","author":"Nelson","year":"1987","journal-title":"Scanning Electron Microscopy"},{"volume-title":"Practical Methods in Electron Microscopy","year":"1974","author":"Glauert","key":"2024092809431984200_bib8"},{"key":"2024092809431984200_bib9","first-page":"88","article-title":"Scanning electron microscopy of micro-corrosion casts","volume":"11","author":"Hodde","year":"1980","journal-title":"Scanning Electron Microscopy"},{"key":"2024092809431984200_bib10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.7326\/0003-4819-77-6-923","article-title":"Acute respiratory distress syndrome in pancreatitis","volume":"77","author":"Interiano","year":"1972","journal-title":"Ann Intern Med"},{"key":"2024092809431984200_bib11","first-page":"71","article-title":"Pulmonary oedema after pancreatitis: role of humoral factors","volume":"10","author":"Malik","year":"1983","journal-title":"Circ Shock"},{"key":"2024092809431984200_bib12","first-page":"15","article-title":"Increased lung vascular permeability after pancreatitis and trypsin infusion","volume":"109","author":"Tahamont","year":"1982","journal-title":"Am J Pathol"},{"key":"2024092809431984200_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/bjs.1800770317","article-title":"The effect of caerulein induced pancreatitis on the hepatic microvasculature","volume":"77","author":"Delaney","year":"1990","journal-title":"Br J Surg"},{"key":"2024092809431984200_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00000658-198807000-00010","article-title":"Pancreatitis induced acute lung injury. 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