{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:16:25Z","timestamp":1790640985468,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Council of Research","award":["88.00047"],"award-info":[{"award-number":["88.00047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This experimental and clinical study examined the relationship between oesophageal damage and optimal pH of refuxate, and whether 24-h pH monitoring at optimal pH could discriminate the severity of oesophagitis. The rabbit oesophagus was perfused in vivo with pepsin and hydrochloric acid solutions of difering pH for 60 min. Maximal oesophageal damage coincided with peptic solutions at pH 1.5\u20132.5. Fifty-nine patients with proven gastro-oesophageal reflux disorders were tested for manometric features of the lower oesophageal sphincter (Pressure, overall length and abdominal length) and oesophageal exposure to different pH levels. They were classified into four groups according to the endoscopically demonstrated severity of oesophagitis. Supine exposure at the optimal pH level for pepsin activity (pH 1.5\u20132.5) and overall sphincter length were found to discriminate the severity of oesophagitis reliably in 75 per cent of cases.<\/jats:p>","DOI":"10.1002\/bjs.1800790222","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:59:42Z","timestamp":1172941182000},"page":"161-164","source":"Crossref","is-referenced-by-count":45,"title":["Oesophagitis and pH of refluxate: an experimental and clinical study"],"prefix":"10.1093","volume":"79","author":[{"given":"G","family":"Zaninotto","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"di Mario","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Costantini","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Baffa","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"German\u00e0","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P L","family":"Dal Santo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bolzan","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Medical Statistics, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Naccarato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ancona","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Padua, OOT , Via Facciolati 71, 35127 Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1992,2,1]]},"reference":[{"key":"2024092810342356100_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-5223(19)37879-1","article-title":"Technique, indications and clinical use of 24-hour esophageal pH monitoring","volume":"79","author":"DeMeester","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092810342356100_bib2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0003-4975(89)90374-3","article-title":"Esophageal function in patients with reflux-induced stricture and its relevance to clinical treatment","volume":"47","author":"Zaninotto","year":"1989","journal-title":"Ann Thorac Surg"},{"key":"2024092810342356100_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM197508072930602","article-title":"Medical and surgical management of reflux esophagitis: a 38 month report on a prospective clinical trial","volume":"293","author":"Behar","year":"1975","journal-title":"N Engl J Med"},{"key":"2024092810342356100_bib4","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0016-5085(86)80017-8","article-title":"Healing and relapse of reflux esophagitis during treatment with ranitidine","volume":"91","author":"Koelz","year":"1986","journal-title":"Gastroenterology"},{"key":"2024092810342356100_bib5","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1007\/BF01535790","article-title":"Utility of inpatient 24-hour intra-esophageal pH monitoring in diagnosis of gastroesophageal reflux","volume":"33","author":"Pujol","year":"1988","journal-title":"Dig Dis Sci"},{"key":"2024092810342356100_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01536157","article-title":"Reliability of 24-hour home esophageal pH monitoring in diagnosis of gastroesophageal reflux","volume":"34","author":"Mattioli","year":"1989","journal-title":"Dig Dis Sci"},{"key":"2024092810342356100_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000171656","article-title":"Gastrooesophageal reflux in Italian healthy volunteers and patients: relationship between gastro-oesophageal reflux, endoscopic oesophagitis and symptoms","volume":"1","author":"Zaninotto","year":"1984","journal-title":"Dig Surg"},{"key":"2024092810342356100_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0016-5085(87)90318-0","article-title":"Optimal thresholds, sensitivity and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease","volume":"93","author":"Schindlebeck","year":"1987","journal-title":"Gastroenterology"},{"key":"2024092810342356100_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1152\/ajplegacy.1975.229.2.496","article-title":"Hydrogen ion transport in the rabbit esophagus","volume":"229","author":"Chung","year":"1975","journal-title":"Am J Physiol"},{"key":"2024092810342356100_bib10","first-page":"135","volume-title":"The Esophagus. Handbook and Atlas of Endoscopy","author":"Savary","year":"1978"},{"key":"2024092810342356100_bib11","first-page":"11","article-title":"Limits of the manual analysis of esophageal manometry and advantages of computerized analysis in the study of esophageal motility","volume":"37","author":"Zaninotto","year":"1991","journal-title":"Minerva Med Gastroenterol"},{"key":"2024092810342356100_bib12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/BF01072193","article-title":"Manometric asymmetry of the lower esophageal high pressure zone","volume":"22","author":"Winans","year":"1977","journal-title":"Dig Dis Sci"},{"key":"2024092810342356100_bib13","first-page":"325","article-title":"Twenty-four hour pH monitoring of distal esophagus: a quantitative measure of gastro-esophageal reflux","volume":"62","author":"Johnson","year":"1974","journal-title":"Am J Gastroenterol"},{"key":"2024092810342356100_bib14","volume-title":"The Analysis of Variance","author":"Scheffe","year":"1959"},{"key":"2024092810342356100_bib15","volume-title":"Multivariate Analysis","author":"Mardia","year":"1979"},{"key":"2024092810342356100_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00004836-198606001-00008","article-title":"Development of the 24-hour intra-esophageal pH monitoring composite scoring system","volume":"8","author":"Johnson","year":"1986","journal-title":"J Clin Gastroenterol"},{"key":"2024092810342356100_bib17","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00000658-198412000-00009","article-title":"Computerized 24-hour ambulatory oesophageal pH monitoring and esophago-gastroduodenoscopy in gastroesophageal reflux: a comparative study","volume":"200","author":"Vitale","year":"1984","journal-title":"Ann Surg"},{"key":"2024092810342356100_bib18","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1016\/S0021-9258(18)69637-1","article-title":"Studies on the optimum pH for the action of pepsin on native and denatured bovine serum albumin and bovine hemoglobin","volume":"234","author":"Schlamowitz","year":"1959","journal-title":"J Biol Chem"},{"key":"2024092810342356100_bib19","first-page":"353","article-title":"The pH-dependence of pepsin catalysed reactions","volume":"113","author":"Cornish-Bowden","year":"1969","journal-title":"Biochemistry"},{"key":"2024092810342356100_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0016-5085(69)80121-6","article-title":"Role of acid and pepsin in acute experimental esophagitis","volume":"56","author":"Goldberg","year":"1969","journal-title":"Gastroenterology"},{"key":"2024092810342356100_bib21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0016-5085(24)05128-X","article-title":"Effect of sleep on swallowing, esophageal peristalsis and acid clearance","volume":"86","author":"Orr","year":"1984","journal-title":"Gastroenterology"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800790222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/79\/2\/161\/59396776\/bjs1800790222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/79\/2\/161\/59396776\/bjs1800790222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T10:34:37Z","timestamp":1727519677000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/79\/2\/161\/6173039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,1]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1992,2,1]]},"published-print":{"date-parts":[[1992,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800790222","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,2]]},"published":{"date-parts":[[1992,2,1]]}}}