{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:22:33Z","timestamp":1761128553032},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Cunningham Trustees"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The management of patients with asymptomatic hyperparathyroidism remains controversial. This study examined the extent to which the presence or prospect of bone disease should influence treatment. Bone mineral content (BMC) of the distal forearm was measured by single photon absorptiometry in 67 patients with mild hyperparathyroidism. Twenty-six patients treated surgically and 17 managed conservatively were reviewed regularly for up to 4 years. Eighty per cent of patients had a baseline fat-corrected BMC within the local reference interval for age and sex, but about 75 per cent of values fell below the mean. BMC at the \u2018distal\u2019 site of the surgically treated patients improved or stabilized, but a continuing decline was seen in the patients managed conservatively (P &amp;lt; 0.01). Differences were small and concern about future osteoporotic fracture should seldom be a major factor in making decisions about surgical correction of mild hyperparathyroidism.<\/jats:p>","DOI":"10.1002\/bjs.1800790327","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:46:49Z","timestamp":1172940409000},"page":"263-265","source":"Crossref","is-referenced-by-count":18,"title":["Bone mineral content in patients with primary hyperparathyroidism: a comparison of conservative management with surgical treatment"],"prefix":"10.1093","volume":"79","author":[{"given":"P A","family":"Mole","sequence":"first","affiliation":[{"name":"Department of Biochemical Medicine Ninewells Hospital and Medical School , Dundee DD1 9SY,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M H","family":"Walkinshaw","sequence":"additional","affiliation":[{"name":"Department of Biochemical Medicine Ninewells Hospital and Medical School , Dundee DD1 9SY,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gunn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ninewells Hospital and Medical School , Dundee DD1 9SY,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C R","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Biochemical Medicine Ninewells Hospital and Medical School , Dundee DD1 9SY,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,3,1]]},"reference":[{"key":"2024092810373238600_bib1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1136\/bmj.296.6628.1016-a","article-title":"Time to end a conservative treatment for mild hyperparathyroidism","volume":"296","author":"Stevenson","year":"1988","journal-title":"Br Med 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hyperparathyroidism","volume":"150","author":"Wishart","year":"1990","journal-title":"Arch Intern Med"},{"key":"2024092810373238600_bib5","first-page":"1063","article-title":"Bone demineralisation, a factor of increasing significance in the management of primary hyperparathyroidism","volume":"106","author":"Block","year":"1989","journal-title":"Surgery"},{"key":"2024092810373238600_bib6","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1210\/jcem-67-6-1294","article-title":"Lack of biochemical progression or continuation of accelerated bone loss in mild asymptomatic primary hyperparathyroidism: evidence for biphasic disease course","volume":"67","author":"Rao","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"2024092810373238600_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.7326\/0003-4819-109-12-959","article-title":"Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral 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