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In this study serial total leucocyte counts and serial C-reactive protein (CRP) concentrations in acute appendicitis were measured. The sensitivity and specificity of serial leucocyte counts in acute appendicitis were 92 and 100 per cent, and for CRP concentrations 69 and 75 per cent, respectively. The sensitivity and specificity of serial total leucocyte counts fulfilled the criteria for a diagnostic test. It is suggested that in patients with equivocal clinical findings, clinical observation combined with serial leucocyte counts may improve decision making.<\/jats:p>","DOI":"10.1002\/bjs.1800790839","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:02:39Z","timestamp":1172941359000},"page":"822-824","source":"Crossref","is-referenced-by-count":55,"title":["Role of sequential leucocyte counts and C-reactive protein measurements in acute appendicitis"],"prefix":"10.1093","volume":"79","author":[{"given":"M M","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary , Leicester LE2 7LX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Underwood","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary , Leicester LE2 7LX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Dookeran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary , Leicester LE2 7LX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary , Leicester LE2 7LX,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R F","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinical Sciences Building, Leicester Royal Infirmary , Leicester LE2 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