{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:54:29Z","timestamp":1788872069318,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["1921-B90-07XA"],"award-info":[{"award-number":["1921-B90-07XA"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"publisher","award":["B90-17X-00640-26B"],"award-info":[{"award-number":["B90-17X-00640-26B"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cyanamid Nordiska"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Male Wistar rats were subjected to colonic resection and randomized to one of four groups: control group (intraperitoneal NaCl, intravenous NaCl); 5-fluorouracil(5-FU) group (intraperitoneal 5-FU, intravenous NaCl); folinic acid group (intraperitoneal NaCl, intravenous, folinic acid); and 5-FU-folinic acid group (intraperitoneal 5-FU, intravenous folinic acid). Treatment was started immediately after surgery and continued until the animals were killed at 3 or 7 days. Anastomotic complications (abscesses or dehiscence) occurred in four of 33 animals in the control group, 12 of 36 in the 5-FU group, one of 32 in the, folinic acid group and nine of 36 in the 5-FU\u2014folinic acid group. Anastomotic and skin breaking strength did not differ between groups on day 3 but by day 7 were significantly reduced in the 5-FU group. In rats given 5-FU\u2014folinic acid, breaking strength was also reduced, but less so than in the 5-FU group. Breaking strength in animals receiving, folinic acid was similar to that in the control group. In this model colonic healing was impaired after intraperitoneal 5-FU administration, but when folinic acid was added no further deterioration occurred.<\/jats:p>","DOI":"10.1002\/bjs.1800790840","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:02:39Z","timestamp":1172923359000},"page":"825-828","source":"Crossref","is-referenced-by-count":33,"title":["Influence of 5-fluorouracil and folinic acid on colonic healing: An experimental study in the rat"],"prefix":"10.1093","volume":"79","author":[{"given":"W","family":"Graf","sequence":"first","affiliation":[{"name":"Department of Surgery, Akademiska Sjukhuset , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Weiber","sequence":"additional","affiliation":[{"name":"Department of Surgery, Allm\u00e4nna Sjukhuset , 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