{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:18Z","timestamp":1740126078956,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The sensitivity of Haemoccult for asymptomatic colorectal carcinoma has been estimated in a large randomized controlled trial of mass population screening, with a minimum follow-up of 2 years. A total of 111 cancers were diagnosed in those who completed the screening tests; of these, 36 appear to have been missed by Haemoccult and 75 were detected by the test, giving an overall sensitivity of 67.6 per cent. Haemoccult was shown to be significantly more sensitive for carcinoma of the sigmoid and descending colon than for rectal or right-sided cancers (81 versus 45 and 47 per cent, respectively). The sensitivity was higher when tests were completed over 6 rather than 3 days (74 versus 65 per cent), but this diference was not statistically significant. There was no evidence for a detrimental effect on tumour stage of a false-negative Haemoccult test; indeed, a higher proportion of the interval cancers were Dukes' A tumours than cancers in the control group.<\/jats:p>","DOI":"10.1002\/bjs.1800790842","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:02:39Z","timestamp":1172941359000},"page":"833-835","source":"Crossref","is-referenced-by-count":24,"title":["Screening for colorectal carcinoma: An analysis of the sensitivity of Haemoccult"],"prefix":"10.1093","volume":"79","author":[{"given":"W M","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Surgery, University Hospital, Queen's Medical Centre , Nottingham NG7 2UH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pye","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital, Queen's Medical Centre , Nottingham NG7 2UH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Hardcastle","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital, Queen's Medical Centre , Nottingham NG7 2UH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital, Queen's Medical Centre , Nottingham NG7 2UH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"2024092811125629600_bib1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/1097-0142(19880801)62:3<645::AID-CNCR2820620333>3.0.CO;2-#","article-title":"Screening and rescreening for colorectal cancer: a controlled trial of faecal occult blood testing in 27 700 subjects","volume":"62","author":"Kewenter","year":"1988","journal-title":"Cancer"},{"key":"2024092811125629600_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00365528909093096","article-title":"Repeated screening for colorectal cancer with faecal occult blood test. 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