{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:14:34Z","timestamp":1787235274397,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In a prospective, randomized, assessor-blind multicentre study two antithrombotic subcutaneous regimens were compared in patients undergoing total hip replacement. Group 1 (1.54 patients) received 750 anti-Xa units of a new low molecular weight heparinoid (Lomoparan) subcutaneously twice a day and group 2 (1.55 patients) received 5000 units heparin and 0.5 mg dihydroergotamine (heparin\u2013DHE 5000) twice a day. The incidence of deep vein thrombosis, assessed by routine bilateral venography on day 10 (\u00b11), was 17 and 32 per cent in groups 1 and 2 respectively (risk reduction 47 per cent; P = 0.007). One patient in each group developed a symptomatic pulmonary embolism confirmed by lung scanning. Major bleeding complications occurred in one patient in each group and no significant difference was observed between the two groups with respect to minor bleeding complications. Subcutaneous Lomoparan appears to be as safe as heparin-DHE 5000 at the above doses with regard to bleeding complications, and is more efficacious with respect to venous thrombosis.<\/jats:p>","DOI":"10.1002\/bjs.1800790919","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T12:21:46Z","timestamp":1172924506000},"page":"911-914","source":"Crossref","is-referenced-by-count":25,"title":["Thromboembolic prophylaxis in total hip replacement: A comparison between the low molecular weight heparinoid Lomoparan and heparindihydroergotamine"],"prefix":"10.1093","volume":"79","author":[{"given":"P","family":"Leyvraz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, H\u00f4pital Orthop\u00e9dique , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bohnet","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H G","family":"Breyer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Barmherzige Schwestern Hospital , Linz,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Estoppey","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, H\u00f4pital Orthop\u00e9dique , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Barmherzige Schwestern Hospital , Linz,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hochreiter","sequence":"additional","affiliation":[{"name":"Department of Trauma and Reconstructive Surgery, Steglitz Hospital , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jakubek","sequence":"additional","affiliation":[{"name":"Department of Trauma and Reconstructive Surgery, Steglitz Hospital , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mair","sequence":"additional","affiliation":[{"name":"Department of Radiology, Steglitz Hospital , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Institute for Experimental Surgery, Technical University , Munich.","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Stiekema","sequence":"additional","affiliation":[{"name":"Organon International , Oss,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"2024092811514686300_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-68863-8","volume-title":"Postoperative Thromboembolism","author":"Bergqvist","year":"1983"},{"key":"2024092811514686300_bib2","first-page":"802","volume-title":"Haemostasis and Thrombosis","author":"Kakkar","year":"1987"},{"key":"2024092811514686300_bib3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0022-4804(77)90030-0","article-title":"The socio-economic effects of an ilio-femoral venous thrombosis","volume":"22","author":"O'Donnell","year":"1977","journal-title":"J Surg Res"},{"key":"2024092811514686300_bib4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1056\/NEJM198805053181805","article-title":"Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. 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