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Eight of the volunteers had a normal response with proximal stimulation and distal inhibition of motility. Only 42 patients (31.6 per cent) had a normal response. The commonest abnormal response (39.1 per cent) was some form of failure of the distal inhibitory reflex. Other patterns of abnormality were an unresponsive oesophagus (15.8 per cent) with no motility change during balloon inflation, or spasm (13.5 per cent) proximal to the balloon. These alterations of secondary peristaltic activity suggest that there are abnormalities of the intrinsic (enteric) nerves of the oesophagus. Different abnormalities were found in patients with similar symptoms. Awareness of this difference might allow a more rational approach to treatment. This hypothesis was tested in a small pilot study treating functional dysphagia with cisapride. Three of nine patients had marked symptomatic improvement within 4 weeks and all three had an unresponsive oesophagus. The remaining six patients, who had failure of distal inhibition or a normal response, did not improve.<\/jats:p>","DOI":"10.1002\/bjs.1800790928","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:21:46Z","timestamp":1172942506000},"page":"938-941","source":"Crossref","is-referenced-by-count":6,"title":["Oesophageal reflex responses: Abnormalities of the enteric nervous system in patients with oesophageal symptoms"],"prefix":"10.1093","volume":"79","author":[{"given":"T","family":"O'Hanrahan","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Manchester, Hope Hospital , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bancewicz","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Manchester, Hope Hospital , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Manchester, Hope Hospital , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Marples","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Manchester, Hope Hospital , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Manchester, Hope Hospital , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"2024092812093612000_bib1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/BF01391368","article-title":"Esophageal manometry - a benefit and cost analysis","volume":"27","author":"Meshkinpour","year":"1982","journal-title":"Dig Dis Sci"},{"key":"2024092812093612000_bib2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/bjs.1800740533","article-title":"Clinical implications of abnormal oesophageal motility","volume":"74","author":"Bancewicz","year":"1987","journal-title":"Br J Surg"},{"key":"2024092812093612000_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1152\/physrev.1958.38.4.533","article-title":"Esophageal motility","volume":"38","author":"Ingelfinger","year":"1958","journal-title":"Physiol Rev"},{"key":"2024092812093612000_bib4","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0016-5085(77)80274-6","article-title":"Neural control of esophageal peristalsis. 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