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A new 24-h pH and motility recording system combined with computerized data analysis was used to study patients with gastro-oesophageal reflux disease and oesophageal motor abnormalities under ambulant conditions. Acid reflux episodes were found to be precipitated by a variety of events with recognizable pressure patterns. Acid clearance abnormalities were demonstrated in patients with erosive oesophagitis but were confined to those with abnormal oesophageal motor function. Improved diagnostic accuracy was demonstrated in the recognition of oesophageal motor disorders.<\/jats:p>","DOI":"10.1002\/bjs.1800791023","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:16:40Z","timestamp":1172938600000},"page":"1056-1060","source":"Crossref","is-referenced-by-count":10,"title":["Ambulatory measurement of oesophageal function: Clinical use of a new pH and motility recording system"],"prefix":"10.1093","volume":"79","author":[{"given":"C P","family":"Barham","sequence":"first","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Marlborough Street, Bristol BS2 8HW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Gotley","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Marlborough Street, Bristol BS2 8HW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Miller","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Marlborough Street, Bristol BS2 8HW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mills","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Marlborough Street, Bristol BS2 8HW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Alderson","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Marlborough Street, Bristol BS2 8HW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"2024092810424280600_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0016-5085(19)33600-5","article-title":"Manometric configuration of the lower esophageal sphincter in normal human subjects","volume":"61","author":"Kaye","year":"1971","journal-title":"Gastroenterotogy"},{"key":"2024092810424280600_bib2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1172\/JCI109667","article-title":"Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects","volume":"65","author":"Dent","year":"1980","journal-title":"J Clin Invest"},{"key":"2024092810424280600_bib3","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/S0016-5085(19)30499-8","article-title":"Normal lower oesophageal sphincter: a comparison of rapid vs slow pull-through techniques","volume":"78","author":"Welch","year":"1980","journal-title":"Gastroenterology"},{"key":"2024092810424280600_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF01296157","article-title":"Esophageal manometry in 95 healthy adult volunteers","volume":"32","author":"Richter","year":"1987","journal-title":"Dig Dis Sci"},{"key":"2024092810424280600_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0016-5085(79)80210-3","article-title":"Achalasia, diffuse esophageal spasm and related motility disorders","volume":"76","author":"Vantrappen","year":"1979","journal-title":"Gastroenterology"},{"key":"2024092810424280600_bib6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1148\/radiology.170.3.2916033","article-title":"Diffuse esophageal spasm: radiographic and manometric correlation","volume":"170","author":"Chen","year":"1989","journal-title":"Radiology"},{"key":"2024092810424280600_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF01312939","article-title":"Is abdominal compression a useful stimulation test for analysis of lower oesophageal sphincter function?","volume":"29","author":"Janisch","year":"1984","journal-title":"Dig Dis Sci"},{"key":"2024092810424280600_bib8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0016-5085(85)90572-4","article-title":"Gastric distention: a mechanism for postprandial gastroesophageal reflux","volume":"89","author":"Holloway","year":"1985","journal-title":"Gastroenterology"},{"key":"2024092810424280600_bib9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/gut.31.5.500","article-title":"Abnormal gastric adaptive relaxation in patients with gastro-oesophageal reflux","volume":"31","author":"Hartley","year":"1990","journal-title":"Gut"},{"key":"2024092810424280600_bib10","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1007\/BF01540040","article-title":"Prospective evaluation of high-dose bethanechol in investigation of esophageal chest pain","volume":"34","author":"Deschner","year":"1989","journal-title":"Dig Dis Sci"},{"key":"2024092810424280600_bib11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/0016-5085(88)90542-2","article-title":"Spontaneous noncardiac chest pain. 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