{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:13:29Z","timestamp":1770977609112,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The integrity of the main pancreatic duct (MPD) was evaluated by endoscopic retrograde pancreatography (ERP) in a retrospective study of 105 patients with acute pancreatitis presenting over an 11-year period (1980\u20131991). The findings were compared with clinical outcome and the need to operate for local pancreatic complications. Patients were divided into two groups. Group 1 (n = 89) had either clinically mild pancreatitis or severe disease but no surgery for local complications, and &amp;lt;25 per cent necrosis on contrast-enhanced computed tomography (CT) (n = 48). Group 2 patients (n = 16) had clinically severe pancreatitis and underwent surgery for local complications and\/or had \u2267 25 per cent necrosis on CT (n = 12), at surgery or post mortem. All 89 patients in group 1 had an intact MPD at ERP, which was performed a median of 6 (range 0\u201330) days after onset of pancreatitis; the median age was 63 (range 20\u201388) years and there were no deaths. The median age of patients in group 2 was 59 (range 26\u201385) years. ERP in this group was performed in four patients &amp;lt;5 days after onset and all had an intact MPD; one died with necrosis and another from a cerebrovascular accident. ERP was performed \u2267 5 days after onset in the other 12 patients: five had an intact MPD and two required surgery for pseudocyst drainage only; seven had a disrupted MPD and all required surgery for pancreatic necrosis (one death). It is concluded that an intact MPD was a feature of mild pancreatitis, whereas disruption occurred &amp;gt;4 days after onset in patients with necrosis necessitating surgery.<\/jats:p>","DOI":"10.1002\/bjs.1800800131","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:23:53Z","timestamp":1172942633000},"page":"94-99","source":"Crossref","is-referenced-by-count":123,"title":["Assessment of main pancreatic duct integrity by endoscopic retrograde pancreatography in patients with acute pancreatitis"],"prefix":"10.1093","volume":"80","author":[{"given":"J P","family":"Neoptolemos","sequence":"first","affiliation":[{"name":"Academic Department of Surgery, Dudley Road Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J M","family":"London","sequence":"additional","affiliation":[{"name":"Academic Department of Surgery, Leicester Royal Infirmary ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Carr-Locke","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Harvard Medical School, Brigham and Women's Hospital , Boston, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"2024092811464642700_bib1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/bjs.1800751123","article-title":"Surgical treatment of acute necrotizing pancreatitis","volume":"75","author":"Wilson","year":"1988","journal-title":"Br J Surg"},{"key":"2024092811464642700_bib2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/gut.33.7.982","article-title":"Sensitivity of diagnostic serum amylase levels: relationship to aetiology and 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