{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:06:03Z","timestamp":1772741163201,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of reflux oesophagitis and acid in the development of oesophageal columnar epithelium was investigated in the rat. Twenty-four animals underwent total gastrectomy and oesophagojejunostomy, inducing reflux of duodenal contents into the oesophagus, and were divided into two groups: an \u2018acid\u2019 group, which drank syrup water with hydrochloric acid (pH 1.8), and a \u2018non-acid\u2019 group, which drank only syrup water (pH 6.5). Four rats were killed at 4, 8 and 12 weeks after surgery. Reflux oesophagitis was found in the lower portion of the oesophagus in all cases. Columnar epithelium was observed in the oesophagus of one rat in the non-acid group at week 8 and of three in the acid group at week 12. These results indicate that the development of columnar epithelium of the oesophagus is preceded by reflux oesophagitis and that acidic conditions may promote this change. Columnar epithelialization may result from metaplasia of squamous epithelium as well as from upward extension of columnar epithelium.<\/jats:p>","DOI":"10.1002\/bjs.1800800420","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:49:19Z","timestamp":1172944159000},"page":"467-470","source":"Crossref","is-referenced-by-count":52,"title":["Role of reflux oesophagitis and acid in the development of columnar epithelium in the rat oesophagus"],"prefix":"10.1093","volume":"80","author":[{"given":"Y","family":"Seto","sequence":"first","affiliation":[{"name":"First Department of Surgery, Faculty of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Kobori","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Faculty of Medicine, University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"2024092812570027200_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/bjs.18003815005","article-title":"Chronic peptic ulcer of the oesophagus and \u2018oesophagitis\u2019","volume":"38","author":"Barrett","year":"1950","journal-title":"Br J Surg"},{"key":"2024092812570027200_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/thx.8.2.87","article-title":"The oesophagus lined with gastric mucous membrane","volume":"8","author":"Allison","year":"1953","journal-title":"Thorax"},{"key":"2024092812570027200_bib3","first-page":"881","article-title":"The lower oesophagus lined by columnar epithelium","volume":"41","author":"Barrett","year":"1977","journal-title":"Surgery"},{"key":"2024092812570027200_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0016-5085(66)80127-0","article-title":"The columnar-lined oesophagus (Barrett syndrome) - acquired condition","volume":"50","author":"Mossberg","year":"1966","journal-title":"Gastroenterology"},{"key":"2024092812570027200_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0003-4975(10)65171-5","article-title":"Conservative operations for peptic oesophagitis with stenosis in columnar-lined lower oesophagus","volume":"13","author":"Naef","year":"1972","journal-title":"Ann Thorac Surg"},{"key":"2024092812570027200_bib6","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0022-5223(19)39666-7","article-title":"Columnar-lined lower oesophagus: an acquired lesion with malignant preposition","volume":"70","author":"Naef","year":"1975","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092812570027200_bib7","first-page":"683","article-title":"The \u2018Barrett syndrome\u2019 (the columnar-lined lower oesophagus): an acquired condition secondary to reflux oesophagitis","volume":"141","author":"Halvorsen","year":"1975","journal-title":"Acta Chirurgica Scandinavica"},{"key":"2024092812570027200_bib8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0016-5085(77)80152-2","article-title":"Regeneration of cardiac type mucosa and acquisition of Barrett mucosa after esophagogastrostomy","volume":"72","author":"Hamilton","year":"1977","journal-title":"Gastroenterology"},{"key":"2024092812570027200_bib9","first-page":"458","article-title":"Barrett's oesophagus","volume":"69","author":"Messian","year":"1978","journal-title":"Am J Gastroenterol"},{"key":"2024092812570027200_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/BF01296897","article-title":"The prevalence of Barrett's oesophagus in patients with chronic peptic oesophageal strictures","volume":"28","author":"Spechler","year":"1983","journal-title":"Dig Dis Sci"},{"key":"2024092812570027200_bib11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0022-5223(19)40115-3","article-title":"Columnar cell-lined oesophagus: assessment of aetiology and treatment","volume":"71","author":"Borne","year":"1976","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024092812570027200_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1001\/archsurg.1968.01340010135015","article-title":"Influence of gastroesophageal incompetence","volume":"97","author":"Hennessy","year":"1968","journal-title":"Arch Surg"},{"key":"2024092812570027200_bib13","first-page":"209","article-title":"Barrett's oesophagus: congenital or acquired? 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