{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:30:05Z","timestamp":1769553005057,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin C is a key antioxidant in human blood plasma and hence could influence the outcome of conditions such as acute pancreatitis in which oxidative stress apparently plays a pivotal role. The concentrations of vitamin C and its immediately bioavailable form, ascorbic acid, in fasting plasma samples from 30 healthy volunteers were compared with those in admission samples from 29 consecutive patients with acute pancreatitis and 27 patients with other acute abdominal crises. Median (range) levels of vitamin C and ascorbic acid, respectively, were 15 (6\u00b73-19) and 12 (4\u00b75-18) \u03bcg\/ml in the control group, 2\u00b78 (0\u00b73-10) and &amp;lt; 0\u00b75 (&amp;lt; 0\u00b75-6\u00b70) \u03bcg\/ml in patients with acute pancreatitis, and 3\u00b77 (0\u00b76-15) and 2\u00b73 (&amp;lt; 0\u00b75-15) \u03bcg\/ml in those with other acute abdominal problems. Admission plasma samples showed equally low vitamin C levels in both groups of patients (P &amp;lt; 0\u00b7001 versus controls), but those from patients with acute pancreatitis were further characterized by a disproportionate reduction in ascorbic acid, such that the concentration of ascorbic acid and its ratio to vitamin C were both significantly lower than in samples from patients with an acute abdomen (P &amp;lt; 0\u00b7005 and P &amp;lt; 0\u00b7001 respectively). It is concluded that the stress of an acute intra-abdominal crisis is accompanied by a non-specific decrease in the plasma level of vitamin C. In acute pancreatitis early and profound oxidative stress compounds this problem by denaturing the available vitamin. There may be a case for the judicious parenteral administration of ascorbic acid to patients with acute pancreatitis to boost plasma antioxidant defence.<\/jats:p>","DOI":"10.1002\/bjs.1800800632","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T18:57:42Z","timestamp":1172948262000},"page":"750-754","source":"Crossref","is-referenced-by-count":68,"title":["Vitamin C status in patients with acute pancreatitis"],"prefix":"10.1093","volume":"80","author":[{"given":"P","family":"Scott","sequence":"first","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bruce","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Schofield","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Shiel","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Braganza","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"McCloy","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Service, Manchester Royal Infirmary , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,6,1]]},"reference":[{"key":"2024092812415627400_bib1","first-page":"357","volume-title":"Free Radicals: Chemistry, Pathology and Medicine","author":"Braganza","year":"1988"},{"key":"2024092812415627400_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/00001574-199010000-00017","article-title":"Experimental acute pancreatitis","volume":"6","author":"Braganza","year":"1990","journal-title":"Current Opinions in Gastroenterology"},{"key":"2024092812415627400_bib3","volume-title":"The Pathogenesis of Pancreatitis","author":"Braganza","year":"1991"},{"key":"2024092812415627400_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4684-5730-8_24","volume-title":"Antioxidants in Therapy and Preventive Medicine","author":"Frei","year":"1990"},{"key":"2024092812415627400_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00006676-198601000-00013","article-title":"Simplified prognostic criteria in acute pancreatitis","volume":"1","author":"Agarwal","year":"1986","journal-title":"Pancreas"},{"key":"2024092812415627400_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-642-71128-2_17","volume-title":"Diagnostic Procedures in Pancreatic Disease","author":"Imrie","year":"1986"},{"key":"2024092812415627400_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(79)62181-X","article-title":"Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids","volume":"62","author":"Omaye","year":"1979","journal-title":"Methods Enzymol"},{"key":"2024092812415627400_bib8","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1042\/bst0181179","article-title":"Problems with the quantitative analysis of dehydroascorbic acid and ascorbic acid in plasma by h.p.l.c","volume":"18","author":"Schofield","year":"1990","journal-title":"Biochem Soc Trans"},{"key":"2024092812415627400_bib9","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1056\/NEJM198604033141407","article-title":"New concepts in the biology and biochemistry of ascobic acid","volume":"314","author":"Levine","year":"1986","journal-title":"N Engl J Med"},{"key":"2024092812415627400_bib10","first-page":"274","article-title":"High intakes of ascorbic acid and urinary oxalate","volume":"35","author":"Hughes","year":"1981","journal-title":"Journal of Human Nutrition"},{"key":"2024092812415627400_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1079\/BJN19820059","article-title":"The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration","volume":"47","author":"Evans","year":"1982","journal-title":"Br J Nutr"},{"key":"2024092812415627400_bib12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1749-6632.1975.tb29302.x","article-title":"Vitamin C status: methods and findings","volume":"258","author":"Sauberlich","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"2024092812415627400_bib13","volume-title":"Role of vitamin C in rheumatoid arthritis","author":"Hughes","year":"1985"},{"key":"2024092812415627400_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01537230","article-title":"Granulocyte elastase in assessment of severity of acute pancreatitis","volume":"35","author":"Gross","year":"1990","journal-title":"Dig Dis Sci"},{"key":"2024092812415627400_bib15","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(86)91017-2","article-title":"Acetylcysteine to treat complications of pancreatitis","volume":"i","author":"Braganza","year":"1986","journal-title":"Lancet"},{"key":"2024092812415627400_bib16","volume-title":"Free radical multisystem disease \u2013 a simple treatment","author":"Holmes","year":"1987"},{"key":"2024092812415627400_bib17","article-title":"Second conference on vitamin C","volume":"258","author":"King","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"2024092812415627400_bib18","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/ajcn\/32.3.530","article-title":"Steady-state turnover and body pool of ascorbic acid in man","volume":"32","author":"Kallner","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"2024092812415627400_bib19","volume-title":"Proceedings of the Second International Meeting of Pancreatology","author":"Braganza","year":"1986"},{"key":"2024092812415627400_bib20","first-page":"561","article-title":"Antioxidants, enzjme induction and chronic pancreatitis: a reappraisal following studies in patients on anticonvulsants","volume":"42","author":"Uden","year":"1988","journal-title":"Eur J Clin Nutr"},{"key":"2024092812415627400_bib21","volume-title":"A dietary investigation of patients with pancreatic disease","author":"Fraine","year":"1985"},{"key":"2024092812415627400_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1079\/BJN19770081","article-title":"The effect of acute illness on leucocyte and plasma ascorbic acid levels","volume":"38","author":"MacLennan","year":"1977","journal-title":"Br J Nutr"},{"key":"2024092812415627400_bib23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/bjs.1800750424","article-title":"Changes in plasma and buffy layer vitamin C following surgery","volume":"75","author":"Vallance","year":"1988","journal-title":"Br J Surg"},{"key":"2024092812415627400_bib24","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1056\/NEJM198611133152009","article-title":"Micronutrients and cancer prevention","volume":"315","author":"Hennekens","year":"1986","journal-title":"N Engl J Med"},{"key":"2024092812415627400_bib25","first-page":"A558","article-title":"Increased lipid isomerization in acute pancreatitis \u2013 evidence of oxidative stress","volume":"32","author":"Kay","year":"1991","journal-title":"Gut"},{"key":"2024092812415627400_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2036.1990.tb00482.x","article-title":"Antioxidant therapy for recurrent pancreatitis: placebocontrolled trial","volume":"4","author":"Uden","year":"1990","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"2024092812415627400_bib27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/gut.32.5.528","article-title":"Effect of a new synthetic ascorbic acid derivative as a free radical scavenger on the development of acute pancreatitis in mice","volume":"32","author":"Nonaka","year":"1991","journal-title":"Gut"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800800632","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/80\/6\/750\/59400582\/bjs1800800632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/80\/6\/750\/59400582\/bjs1800800632.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T12:42:07Z","timestamp":1727527327000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/80\/6\/750\/6175692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,1]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1993,6,1]]},"published-print":{"date-parts":[[1993,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800800632","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,6]]},"published":{"date-parts":[[1993,6,1]]}}}