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These are usually of little clinical consequence and can be treated by increasing the rate of administration of the lytic agent. However, in some patients the clinical condition of the limb deteriorates rapidly. In an attempt to define the incidence of acute limb deterioration during IAT, information was collected from five centres in the UK with experience of the technique. A total of 866 treatments were recorded, with 20 limbs (2\u00b73 per cent) undergoing acute deterioration. This complication was more common during the treatment of thrombosed popliteal aneurysm than during that of emboli or thrombosed atheromatous arteries or grafts (P &amp;lt;0\u00b7001). The amputation rate associated with the complication was high, and operative intervention provided better results than continuation of lysis.<\/jats:p>","DOI":"10.1002\/bjs.1800800914","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:33:19Z","timestamp":1172950399000},"page":"1118-1120","source":"Crossref","is-referenced-by-count":52,"title":["Acute limb deterioration during intra-arterial thrombolysis"],"prefix":"10.1093","volume":"80","author":[{"given":"R B","family":"Galland","sequence":"first","affiliation":[{"name":"Departments of Surgery, Royal Berkshire Hospital , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Earnshaw","sequence":"additional","affiliation":[{"name":"Gloucestershire Royal Hospital , Nottingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R N","family":"Baird","sequence":"additional","affiliation":[{"name":"Bristol Royal Infirmary 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