{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:36:05Z","timestamp":1792146965307,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gastrointestinal lymphoma, uncommon in the West, is far more prevalent in developing countries where it falls into two groups: \u2018Western\u2019-type lymphomas, similar to those seen in developed countries, and the so-called Mediterranean-type lymphoma. It is now accepted that Mediterranean lymphoma represents, in the majority if not in all cases, the late stage of \u03b1 heavy chain disease (\u03b1-HCD). This disease is characterized by abnormal secretion of an immunoglobulin fragment; \u03b1-HCD and Mediterranean lymphoma constitute two ends of a spectrum of pathology now classified as immunoproliferative small intestinal disease (IPSID). IPSID is associated predominantly with poor socioeconomic conditions; patients present with progressive malabsorption in the second and third decades of life. Diagnosis is established by small bowel biopsy, with or without high serum levels of the \u03b1 heavy chain protein. Treatment consists of an initial staging laparotomy, with debulking of lymphomatous deposits if appropriate, followed by chemotherapy or radiotherapy. Overall prognosis is poor but the recent use of doxorubicinbased chemotherapy offers some hope for the future.<\/jats:p>","DOI":"10.1002\/bjs.1800810107","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:24:48Z","timestamp":1172949888000},"page":"20-24","source":"Crossref","is-referenced-by-count":37,"title":["Immunoproliferative small intestinal disease: Mediterranean lymphoma and \u03b1 heavy chain disease"],"prefix":"10.1093","volume":"81","author":[{"given":"I G","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Surgery, Pontefract General Infirmary , Pontefract,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M I","family":"Aldoori","sequence":"additional","affiliation":[{"name":"Department of Surgery, Pontefract General Infirmary , Pontefract,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"2024092813161241800_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/1097-0142(196201\/02)15:1<66::AID-CNCR2820150111>3.0.CO;2-G","article-title":"Cancer in Lebanon and the near East","volume":"15","author":"Azar","year":"1962","journal-title":"Cancer"},{"key":"2024092813161241800_bib2","first-page":"221","article-title":"Malabsorption syndrome in lymphoma of small intestine","volume":"1","author":"Ramot","year":"1965","journal-title":"Isr J Med Sci"},{"key":"2024092813161241800_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0016-5085(19)34098-3","article-title":"Intractable watery diarrhoea, hypokalaemia and malabsorption in a patient with Mediterranean type of abdominal lymphoma","volume":"55","author":"Seijffers","year":"1968","journal-title":"Gastroenterlogy"},{"key":"2024092813161241800_bib4","first-page":"151","article-title":"IgA abnormalities in abdominal lymphoma (\u03b1-chain disease)","volume":"5","author":"Seligmann","year":"1969","journal-title":"Isr J Med Sci"},{"key":"2024092813161241800_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-4615-8930-3_4","article-title":"Structural variants of human immunoglobulins","volume":"4","author":"Franklin","year":"1975","journal-title":"Contemp Top Mol Immunol"},{"key":"2024092813161241800_bib6","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.109.5.1131","article-title":"Alpha and gamma heavy chain diseases in man: intracellular origin of the aberrant polypeptides","volume":"109","author":"Buxbaum","year":"1972","journal-title":"J Immunol"},{"key":"2024092813161241800_bib7","first-page":"283","article-title":"Cellular immunoglobulins in human \u03b3 and \u03b1 heavy chain diseases","volume":"37","author":"Preud'homme","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"2024092813161241800_bib8","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM198306093082309","article-title":"Current concepts: immunoproliferative small intestinal disease. 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