{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:54:24Z","timestamp":1770432864539,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In 51 hospitals in six European countries 713 patients requiring below\u2013knee amputation for ischaemic disease were studied prospectively. The patients were allocated randomly to receive standard postoperative treatment or standard treatment plus intravenous infusion of the prostacyclin analogue iloprost for 6 h per day over 14\u201321 days. Healing of the amputation stump and the need for reamputation at a higher level were similar in the two groups. Overall at 3 months 59 per cent of stumps had healed, 19 per cent of patients had required reamputation at a higher level, 11 per cent had died and the remaining 11 per cent remained with unhealed stumps. Preoperative characteristics were analysed as possible risk factors or markers for primary healing, reamputation and death. Previous arterial reopening procedures (surgical or radiological) almost doubled the chances of primary stump healing (P&amp;lt;0\u201305). The surgeon's assessment of the likelihood of healing was wrong in 21 per cent of cases in which the operating surgeon thought that healing would probably occur and in 52 per cent of those in which it was thought healing was improbable.<\/jats:p>","DOI":"10.1002\/bjs.1800810110","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:24:48Z","timestamp":1172949888000},"page":"33-37","source":"Crossref","is-referenced-by-count":66,"title":["Prospective study of 713 below\u2013knee amputations for ischaemia and the effect of a prostacyclin analogue on healing"],"prefix":"10.1093","volume":"81","author":[{"given":"J","family":"Dormandy","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, St George's Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Belcher","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Clinical Research , Schering, Berlin,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Broos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Universiteit Ziekenhuis St Pieter , Leuven,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospital Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Laszlo","sequence":"additional","affiliation":[{"name":"Orszagos Orvosi Rehabilitacios Intezet , Szanatorium Utca 2, Budapest,","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Community Hospital , Kalmaz,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Moggi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Istituto di Patologia Guviwigica ; Perugia,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Clinical Research , Schering, Berlin,","place":["Germany"]},{"name":"Department of Biometrics , Schering, Berlin,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"2024092813195965900_bib1","first-page":"11","volume-title":"Limb Salvage and Amputation for Vascular Disease","author":"Dormandy","year":"1988"},{"key":"2024092813195965900_bib2","first-page":"85","volume-title":"Limb Salvage and Amputation for Vascular Disease","author":"Deane","year":"1988"},{"key":"2024092813195965900_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0950-821X(05)80894-1","article-title":"Selection of amputation level: a review","volume":"5","author":"Sarin","year":"1991","journal-title":"Eur J Vasc Surg"},{"key":"2024092813195965900_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0950-821X(05)80781-9","article-title":"Non\u2013surgical treatment of critical limb ischaemia","volume":"4","author":"Norgren","year":"1990","journal-title":"Eur J Vasc Surg"},{"key":"2024092813195965900_bib5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1055\/s-2008-1066673","article-title":"Iloprost, ein stabiles Prostacyclinderivat bei arterieller Vershlusskrankheit im Stadium IV","volume":"114","author":"Diehm","year":"1989","journal-title":"Dtsch Med Wochenschr"},{"key":"2024092813195965900_bib6","first-page":"379","article-title":"Placebo\u2013kontrollierte, doppel\u2013blinde Multicenterstudie zur Wirksamkeit von Iloprost bei der Behandlung ischamischer Ruheschmerzen von Patientenmit peripheren arteriellen Durchblutungsstorungen","volume":"20","author":"Balzer","year":"1987","journal-title":"Vasa"},{"key":"2024092813195965900_bib7","first-page":"335","volume-title":"Cardiovascular Significance of Endothelium\u2013Derived Vasoactive Factors","author":"Dormandy","year":"1991"},{"key":"2024092813195965900_bib8","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1001\/jama.1987.03390170074031","article-title":"Leukocytes and the risk of ischemic diseases","volume":"257","author":"Ernst","year":"1987","journal-title":"JAMA"},{"key":"2024092813195965900_bib9","first-page":"166","article-title":"Preoperative haemoglobin as predictor of outcome of diabetic amputations","volume":"ii","author":"Bailey","year":"1979","journal-title":"Lancet"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800810110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/81\/1\/33\/59402490\/bjs1800810110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/81\/1\/33\/59402490\/bjs1800810110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T13:20:09Z","timestamp":1727529609000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/81\/1\/33\/6165079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1994,1,1]]},"published-print":{"date-parts":[[1994,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800810110","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,1]]},"published":{"date-parts":[[1994,1,1]]}}}