{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:46Z","timestamp":1763036206692},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The outcome of patients with cholesterolosis was compared with that of those with chronic cholecystitis operated on for chronic acalculous biliary pain. A total of 55 patients with acalculous biliary pain with a median symptom duration of 24 (range 6\u2013120) months were investigated by dynamic cholescintigraphy and followed for a median of 24 (range 12\u201360) months. Thirty-five patients underwent cholecystectomy, of whom 22 had a low gallbladder ejection fraction (under 35 per cent), with symptomatic improvement in 21 of these (P&amp;lt;0\u00b701). All four patients with a normal ejection fraction (35\u201350 per cent) improved after cholecystectomy but only four of nine with a high ejection fraction (over 50 per cent) did so. Results of histological examination were available in 32 patients and revealed cholesterolosis in 20. A low ejection fraction was found in 16 patients with cholesterolosis, of whom 15 showed symptomatic improvement after cholecystectomy; the other four patients had a high fraction and all improved after cholecystectomy. Overall, symptoms in 19 of 20 patients with cholesterolosis improved after cholecystectomy compared with only seven of 12 with chronic cholecystitis (P=0\u00b703).<\/jats:p>","DOI":"10.1002\/bjs.1800810141","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:24:48Z","timestamp":1172949888000},"page":"112-115","source":"Crossref","is-referenced-by-count":18,"title":["Cholesterolosis in patients with chronic acalculous biliary pain"],"prefix":"10.1093","volume":"81","author":[{"given":"W A","family":"Kmiot","sequence":"first","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E P","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J R","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Wolverson","sequence":"additional","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L K","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Neoptolemos","sequence":"additional","affiliation":[{"name":"Department of Surgery , Dudley Road Hospital, Birmingham B18 7QH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"2024092813204260500_bib1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/bjs.1800750516","article-title":"Clinical application of the cholecystokinin provocation test","volume":"75","author":"Sunderland","year":"1988","journal-title":"Br J Surg"},{"key":"2024092813204260500_bib2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2214\/ajr.159.3.1503014","article-title":"Chronic biliary-type pain in the absence of gallstones: the value of cholecystokinin cholescintigraphy","volume":"159","author":"Kloiber","year":"1992","journal-title":"AJR Am J Roentgenol"},{"key":"2024092813204260500_bib3","first-page":"1695","article-title":"Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease","volume":"32","author":"Fink-Bennett","year":"1991","journal-title":"J Nucl Med"},{"key":"2024092813204260500_bib4","first-page":"21","article-title":"Cholecystokinin enhanced hepatobiliary scanning with ejection fraction calculation as an indicator of disease of the gallbladder","volume":"172","author":"Zech","year":"1991","journal-title":"Surg Gynecol Obstet"},{"key":"2024092813204260500_bib5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archsurg.1991.01410320039003","article-title":"Results of surgical therapy for biliary dyskinesia","volume":"126","author":"Misra","year":"1991","journal-title":"Arch Surg"},{"key":"2024092813204260500_bib6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/0016-5085(91)90540-2","article-title":"Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy","volume":"101","author":"Yap","year":"1991","journal-title":"Gastroenterology"},{"key":"2024092813204260500_bib7","first-page":"275","article-title":"Cholecystitis without stones","volume":"22","author":"Mackey","year":"1934","journal-title":"Br J Surg"},{"key":"2024092813204260500_bib8","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2214\/ajr.139.6.1117","article-title":"Cholecystokinin, cholecystography, sonography and scintigraphy: detection of chronic acalculous cholecystitis","volume":"139","author":"Davis","year":"1982","journal-title":"AJR Am J Roentgenol"},{"key":"2024092813204260500_bib9","first-page":"986","article-title":"Chronic right upper quadrant pain without gallstones. 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