{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:57:52Z","timestamp":1758905872299,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human mesothelial cells synthesize plasminogen activator inhibitor (PAI) 1 in inflamed peritoneal tissue. The role of tumour necrosis factor (TNF) in the mediation of this response was studied. Postoperative peritoneal drain fluid contained both TNF and PAI-1. Peak levels of TNF at 4 h (median 271 pg\/ml) preceded a rise in PAI-1 concentration, which peaked at 18 h (median 943\u00b71 ng\/ml). Thus TNF may mediate increased PAI-1 release in inflamed peritoneum. TNF significantly increased the mean(s.e.m.) release of PAI-1 by human peritoneal mesothelial cells in vitro at 4 h (control 1\u00b784(0\u00b717) ng\/\u03bcg versus TNF 2\u00b737(0\u00b717) ng\/\u03bcg, P0\u00b705), 6 h (2\u00b753(0\u00b709) versus 3\u00b788(0\u00b746) ng\/\u03bcg, P&amp;lt;0\u00b705), 18 h (0\u00b750(0\u00b702) versus 1\u00b704(0\u00b711) ng\/\u03bcg, P&amp;lt;0\u00b705) and 24 h (0\u00b787(0\u00b705) versus 1\u00b735(0\u00b711)ng\/\u03bcg, P&amp;lt;0\u00b705). TNF may be an important mediator of PAI-1 production by human mesothelial cells during peritoneal inflammation.<\/jats:p>","DOI":"10.1002\/bjs.1800810218","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:08:19Z","timestamp":1172952499000},"page":"214-216","source":"Crossref","is-referenced-by-count":38,"title":["Tumour necrosis factor-mediated release of plasminogen activator inhibitor 1 by human peritoneal mesothelial cells"],"prefix":"10.1093","volume":"81","author":[{"given":"S A","family":"Whawell","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Scott-Coombes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M N","family":"Vipond","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Tebbutt","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,2,1]]},"reference":[{"key":"2024092814313670100_bib1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/bjs.1800760422","article-title":"Reduced human peritoneal plasminogen activating activity: a possible mechanism of adhesion formation","volume":"76","author":"Thompson","year":"1989","journal-title":"Br J Surg"},{"key":"2024092814313670100_bib2","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/0140-6736(90)91125-T","article-title":"Peritoneal fibrinolytic activity and intra-abdominal adhesions","volume":"ii","author":"Vipond","year":"1990","journal-title":"Lancet"},{"key":"2024092814313670100_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.1711690111","article-title":"Localisation of plasminogen activator inhibitor-1 production in inflamed appendix by in situ mRNA 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