{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:21:04Z","timestamp":1793845264179,"version":"4.6.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008954","name":"Soci\u00e9t\u00e9 Francaise de Nutrition Ent\u00e9rale et Parent\u00e9rale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008954","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical School of Marseille, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A study was performed to attempt to modify the healing response to severe oesophageal corrosive burns to prevent complications. The study was performed on four groups each of 15 Wistar rats: a control group, an untreated group and groups given epidermal growth factor (EGF) alone or EGF for 5 days and interferon (IFN) \u03b3 from the sixth to 20th day. In the last three groups an oesophageal lesion was induced with 2\u20135 moll\u22121 sodium hydroxide solution. The efficacy of treatment was assessed on days 2, 5 and 20 by measurement of weight gain, oesophageal internal lumen, stenosis index (wall thickness: lumen diameter) and collagen production. On day 5, collagen synthesis was significantly (P&amp;lt;0.05) higher in rats given EGF than in the untreated group. On day 20, no significant difference was seen in weight gain between the control rats and either treated group and stenoses were present in all untreated rats and in none of the treated group. The stenosis index on day 20 was lower in the groups given EGF and EGF-IFN-\u03b3 than in untreated rats (P&amp;lt;0.05) and collagen production was significantly (P&amp;lt;0.05) lower in the group given EGF and IFN-\u03b3 than in the other animals. The sequential use of EGF and IFN-\u03b3 significantly reduced the frequency of residual stenosis.<\/jats:p>","DOI":"10.1002\/bjs.1800810325","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:04:37Z","timestamp":1172952277000},"page":"395-398","source":"Crossref","is-referenced-by-count":41,"title":["Influence of epidermal growth factor and interferon \u03b3 on healing of oesophageal corrosive burns in the rat"],"prefix":"10.1093","volume":"81","author":[{"given":"B","family":"Berthet","sequence":"first","affiliation":[{"name":"Department of Surgery, Hopital de la Conception , 147 Boulevard Baile, 13 385 Marseille,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Di Costanzo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hopital de la Conception , 147 Boulevard Baile, 13 385 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