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All patients underwent standardized en bloc oesophagectomy and lymph node dissection with prospective documentation of the histopathological findings; follow-up was complete. Multivariate analysis identified the Union Internacional Contra la Cancrum R category (i.e. the presence of residual tumour after resection) as the most important independent prognostic factor (P&amp;lt; 0.001) followed by the ratio of invaded to removed lymph nodes (P&amp;lt; 0.001). These data suggest that only patients in whom R0 resection can be anticipated based on preoperative assessment should undergo primary resection for oesophageal cancer. Extended lymphadenectomy may improve survival in patients with a limited number of invaded mediastinal nodes.<\/jats:p>","DOI":"10.1002\/bjs.1800810330","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:04:37Z","timestamp":1172952277000},"page":"410-413","source":"Crossref","is-referenced-by-count":245,"title":["Ratio of invaded to removed lymph nodes as a predictor of survival in squamous cell carcinoma of the oesophagus"],"prefix":"10.1093","volume":"81","author":[{"given":"J D","family":"Roder","sequence":"first","affiliation":[{"name":"Department of Surgery, Technische Universit\u00e4t M\u00fcnchen , Ismaninger Stra\u00dfe 22,81675 Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Section of Statistics and Epidemiology, Technische Universit\u00e4t M\u00fcnchen , Ismaninger Stra\u00dfe 22,81675 Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Technische Universit\u00e4t M\u00fcnchen , Ismaninger Stra\u00dfe 22,81675 Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Fink","sequence":"additional","affiliation":[{"name":"Department of Surgery, Technische Universit\u00e4t M\u00fcnchen , Ismaninger Stra\u00dfe 22,81675 Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Siewert","sequence":"additional","affiliation":[{"name":"Department of Surgery, Technische Universit\u00e4t M\u00fcnchen , Ismaninger Stra\u00dfe 22,81675 Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"2024092814455100600_bib1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/978-4-431-68246-2_146","volume-title":"Diseases of the Esophagus","author":"Fink","year":"1993"},{"key":"2024092814455100600_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF01272555","article-title":"En-bloc Resektion der Speiser\u00f6hre beim Oesophaguscarcinom","volume":"373","author":"Siewert","year":"1988","journal-title":"Langenbecks Arch Chir"},{"key":"2024092814455100600_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0011-3840(80)80025-6","article-title":"Surgery for carcinoma of the esophagus","volume":"17","author":"Akiyama","year":"1980","journal-title":"Curr Probl Surg"},{"key":"2024092814455100600_bib4","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-83920-7","volume-title":"Histological Typing of Oesophageal and Gastric Tumours","author":"Watanabe","year":"1990","edition":"2nd"},{"key":"2024092814455100600_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-82982-6","volume-title":"UICC TNM Classification of Malignant Tumors","author":"Hermanek","year":"1987","edition":"4th"},{"key":"2024092814455100600_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"2024092814455100600_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/biomet\/52.1-2.203","article-title":"A generalized Wilcoxon test for comparing arbitrarily single-censored samples","volume":"52","author":"Gehan","year":"1965","journal-title":"Biometrika"},{"key":"2024092814455100600_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables (with discussion)","volume":"B34","author":"Cox","year":"1972","journal-title":"J R Stat Soc"},{"key":"2024092814455100600_bib9","first-page":"219","volume-title":"Diseases of the Esophagus. 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