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The frequency of postoperative seroma formation was also decreased by tranexamic acid administration (27 versus 37 per cent, P = 0\u00b72). Haematoma formation was infrequent in both groups and was not altered by administration of tranexamic acid. No infectious complications occurred. Age over 60 years was a significant risk factor for overall wound complications but tumour size and regional lymph node metastases were not. Tranexamic acid may be used to reduce the frequency of postoperative wound complications following surgery for breast cancer.<\/jats:p>","DOI":"10.1002\/bjs.1800810621","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:31:11Z","timestamp":1172953871000},"page":"856-859","source":"Crossref","is-referenced-by-count":107,"title":["Perioperative and postoperative tranexamic acid reduces the local wound complication rate after surgery for breast cancer"],"prefix":"10.1093","volume":"81","author":[{"given":"D","family":"Oertli","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Laffer","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Haberthuer","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, University Hospital , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Department of Consult AG, Statistical Consulting Company , Berne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital , Basel,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"2024092814422046800_bib1","first-page":"327","article-title":"Prevention of seromas following mastectomy and axillary dissection","volume":"158","author":"Aitken","year":"1984","journal-title":"Surg Gynecol Obsstet"},{"key":"2024092814422046800_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1445-2197.1984.tb06680.x","article-title":"Wound healing following mastectomy","volume":"54","author":"Hayes","year":"1984","journal-title":"Aust N Z J Surg"},{"key":"2024092814422046800_bib3","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/bjs.1800720714","article-title":"Complications and hospital stay after surgery for breast cancer: a prospective study of 385 patients","volume":"72","author":"Tejler","year":"1985","journal-title":"Br J Surg"},{"key":"2024092814422046800_bib4","first-page":"27","article-title":"Pr\u00e9vention des lymphoc\u00e8les postoperatoires apr\u00e8s amputation du sein","volume":"14","author":"Salmon","year":"1985","journal-title":"Presse Med"},{"key":"2024092814422046800_bib5","first-page":"483","article-title":"Postmastectomy seromas and wound drainage","volume":"165","author":"Tadych","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"2024092814422046800_bib6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/bjs.1800741239","article-title":"Postoperative seroma following mastectomy and axillary dissection","volume":"74","author":"Bryant","year":"1987","journal-title":"Br J Surg"},{"key":"2024092814422046800_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3109\/02841868809091765","article-title":"Total mastectomy with special reference to surgical technique, extent of axillary dissection and complications","volume":"27","author":"Watt-Boolsen","year":"1988","journal-title":"Acta Oncol"},{"key":"2024092814422046800_bib8","first-page":"392","article-title":"Morbidit\u00e9 du traitement chirurgical du cancer du sein avance apr\u00e9s irradiation","volume":"44","author":"Guenier","year":"1990","journal-title":"Ann Chir"},{"key":"2024092814422046800_bib9","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/0002-9610(91)90905-S","article-title":"Wound complications after modified radical mastectomy compared with tylectomy with axillary lymph node dissection","volume":"161","author":"Vinton","year":"1991","journal-title":"Am J Surg"},{"key":"2024092814422046800_bib10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00000658-198410000-00016","article-title":"Lumpectomy and level I axillary dissection prior to irradiation for operable breast cancer","volume":"200","author":"Schwartz","year":"1984","journal-title":"Ann Surg"},{"key":"2024092814422046800_bib11","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/archsurg.1990.01410210070010","article-title":"Level I and II axillary dissection in the treatment of early-stage breast cancer. 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