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After a median follow-up of 7\u00b75 years, local recurrence occurred in three of 46 women and 15 of 71 men (P = 0\u00b703). The survival rates at 5 years were 71 per cent for women (95 per cent confidence interval 56\u201383 per cent) and 60 per cent for men (95 per cent confidence interval 50\u201371 per cent) (P &amp;lt; 0\u00b705). The risk for distant metastasis was comparable, suggesting an influence of local recurrence on survival. Reduction of the local recurrence rate coincides with the higher proportion of anterior extensions of surgery in women (19 of 47) than in men (two of 72).<\/jats:p>","DOI":"10.1002\/bjs.1800810851","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:03:15Z","timestamp":1172955795000},"page":"1227-1229","source":"Crossref","is-referenced-by-count":16,"title":["Effect of extent of anterior resection and sex on disease-free survival and local recurrence in patients with rectal cancer"],"prefix":"10.1093","volume":"81","author":[{"given":"L M D","family":"Buhre","sequence":"first","affiliation":[{"name":"Department of Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N H","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"de Ruiter","sequence":"additional","affiliation":[{"name":"Department of Urology, Groningen, Groningen University Hospital ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"van Loon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Groningen University Hospital , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C J","family":"Verschueren","sequence":"additional","affiliation":[{"name":"Department of Surgery, Groningen University Hospital , Groningen,","place":["The Netherlands"]},{"name":"Comprehensive Cancer Centre , Groningen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,8,1]]},"reference":[{"key":"2024092815391845200_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bjs.1800720115","article-title":"Local recurrence after potentially curative resection for rectal cancer in a series of 1008 patients","volume":"72","author":"McDermott","year":"1985","journal-title":"Br J Surg"},{"key":"2024092815391845200_bib2","first-page":"340","article-title":"Adenocarcinoma of the rectum: incidence and locations of recurrent tumor following present-day operations performed for cure","volume":"151","author":"Gilbertsen","year":"1960","journal-title":"Arch Surg"},{"key":"2024092815391845200_bib3","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/1097-0142(19840315)53:6<1354::AID-CNCR2820530623>3.0.CO;2-J","article-title":"Patterns of pelvic recurrence following definitive resections of rectal cancer","volume":"53","author":"Pilipshen","year":"1984","journal-title":"Cancer"},{"key":"2024092815391845200_bib4","first-page":"496","article-title":"The clinical correlation of an autopsy study of recurrent colorectal cancer","volume":"189","author":"Welch","year":"1979","journal-title":"Ann Surg"},{"key":"2024092815391845200_bib5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0140-6736(86)92612-7","article-title":"Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. 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