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There were 24 patients with dysplastic epithelium, nine with regenerative atypia, 18 with benign histology and 19 with adenocarcinoma arising in Barrett's epithelium. The PCNA index of malignant tissue was significantly different from that of benign (P &amp;lt; 0.001) and dysplastic (P &amp;lt; 0.05) specimens. PCNA indices in histologically normal Barrett's epithelium adjacent to a tumour were significantly different (P &amp;lt; 0.001) from those in normal Barrett's epithelium with no adjacent tumour. These findings support the use of PCNA measurement in the assessment of Barrett's epithelium.<\/jats:p>","DOI":"10.1002\/bjs.1800811219","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:43:23Z","timestamp":1172951003000},"page":"1766-1768","source":"Crossref","is-referenced-by-count":24,"title":["Proliferating cell nuclear antigen in the assessment of Barrett's mucosa"],"prefix":"10.1093","volume":"81","author":[{"given":"P","family":"Gillen","sequence":"first","affiliation":[{"name":"Department of Surgery, St James's Hospital and Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Histopathology, St James's Hospital and Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Grehan","sequence":"additional","affiliation":[{"name":"Department of Histopathology, St James's Hospital and Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D O'B","family":"Hourihane","sequence":"additional","affiliation":[{"name":"Department of Histopathology, St James's Hospital and Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P J","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Department of Surgery, St James's Hospital and Trinity College Dublin , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1994,12,1]]},"reference":[{"key":"2024092814290069100_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1056\/NEJM198608073150605","article-title":"Barrett's esophagus","volume":"315","author":"Spechler","year":"1986","journal-title":"N Engl J Med"},{"key":"2024092814290069100_bib2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0046-8177(92)90121-I","article-title":"Adenocarcinoma in Barrett's esophagus: a new epidemic?","volume":"23","author":"Haggitt","year":"1992","journal-title":"Hum Pathol"},{"key":"2024092814290069100_bib3","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/0016-5085(92)90758-Q","article-title":"Flow-cytometric and histological progression to malignancy in Barrett's esophagus: prospective endoscopic surveillance of a cohort","volume":"102","author":"Reid","year":"1992","journal-title":"Gastroenterology"},{"key":"2024092814290069100_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0046-8177(88)80344-7","article-title":"Observer variation in the diagnosis of dysplasia in Barrett's esophagus","volume":"19","author":"Reid","year":"1988","journal-title":"Hum Pathol"},{"key":"2024092814290069100_bib5","first-page":"1165","article-title":"Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies. 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