{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:36:11Z","timestamp":1772768171602,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study examined a possible aetiological agent, namely, Helicobacter pylori, in perforated peptic ulcer disease and its relationship to persisting ulcer. Twenty-nine patients with perforated peptic ulcer underwent simple closure of the perforation at laparotomy. A 13C urea breath test carried out on the eighth day after operation was positive in 24 patients. Fourteen of 17 patients who underwent upper gastrointestinal endoscopy 6 weeks after discharge from hospital had a positive 13C urea breath test. The biopsy urease test performed on mucosal samples taken at endoscopy was positive in 12 of these 14 patients, indicating continuing active infection with H. pylori. Seven patients with positive 13C urea breath and biopsy urease tests had persisting duodenal ulceration. None of the three patients with a negative 13C urea breath test had evidence of duodenal ulceration at endoscopy. The association between a high rate of duodenal ulcer persistence and a high incidence of H. pylori infection suggests that antibiotic therapy to eradicate this microorganism should be given to all patients with perforated peptic ulcer disease.<\/jats:p>","DOI":"10.1002\/bjs.1800820325","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:36:09Z","timestamp":1172957769000},"page":"360-362","source":"Crossref","is-referenced-by-count":82,"title":["<i>Helicobacter pylori<\/i> infection in perforated peptic ulcer disease"],"prefix":"10.1093","volume":"82","author":[{"given":"M","family":"Sebastian","sequence":"first","affiliation":[{"name":"Department of Surgery, Al Ain Hospital, U.A.E. University , Al Ain,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V P Prem","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Al Ain Hospital, U.A.E. University , Al Ain,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y I M","family":"Elashaal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Al Ain Hospital, U.A.E. University , Al Ain,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J W","family":"Sim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, U.A.E. University , Al Ain,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"2024092814523273300_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00000658-198801000-00002","article-title":"Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists","volume":"207","author":"Christensen","year":"1988","journal-title":"Ann Surg"},{"key":"2024092814523273300_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/bjs.1800740203","article-title":"Perforated duodenal ulcer","volume":"74","author":"Raimes","year":"1987","journal-title":"Br J Surg"},{"key":"2024092814523273300_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/bjs.1800770126","article-title":"Simple closure of perforated duodenal ulcer: a prospective evaluation of a conservative management policy","volume":"77","author":"Bornman","year":"1990","journal-title":"Br J Surg"},{"key":"2024092814523273300_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000171339","article-title":"Perforated peptic ulcer - the changing scene","volume":"10","author":"Cocks","year":"1992","journal-title":"Dig Dis"},{"key":"2024092814523273300_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/bjs.1800740210","article-title":"Effect of cimetidine on prognosis after simple closure of perforated duodenal ulcer","volume":"74","author":"Simpson","year":"1987","journal-title":"Br J Surg"},{"key":"2024092814523273300_bib6","first-page":"240","article-title":"Duodenal ulcer perforation: the effect of H2 antagonists?","volume":"68","author":"Gillen","year":"1986","journal-title":"Ann R Coll Surg Engl"},{"key":"2024092814523273300_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0016-5085(93)90038-E","article-title":"Helicobacter pylori: current status","volume":"105","author":"Graham","year":"1993","journal-title":"Gastroenterology"},{"key":"2024092814523273300_bib8","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(90)91301-P","article-title":"Cure of duodenal ulcer associated with eradication of Helicobacter pylori","volume":"335","author":"Rauws","year":"1990","journal-title":"Lancet"},{"key":"2024092814523273300_bib9","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/gut.30.8.1058","article-title":"Detection of Campylobacter pylori by the biopsy urease test: an assessment in 1445 patients","volume":"30","author":"McNulty","year":"1989","journal-title":"Gut"},{"key":"2024092814523273300_bib10","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0140-6736(87)92145-3","article-title":"Campylobacter pylori detected noninvasively by 13C-urea breath test","volume":"i","author":"Graham","year":"1987","journal-title":"Lancet"},{"key":"2024092814523273300_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF01658109","article-title":"Perforated duodenal ulcers","volume":"11","author":"Boey","year":"1987","journal-title":"World J Surg"},{"key":"2024092814523273300_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0039-6109(16)45682-3","article-title":"Current surgical management of duodenal ulcers","volume":"72","author":"Stabile","year":"1992","journal-title":"Surg Clin North Am"},{"key":"2024092814523273300_bib13","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(88)90929-4","article-title":"Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori","volume":"ii","author":"Marshall","year":"1988","journal-title":"Lancet"},{"key":"2024092814523273300_bib14","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1056\/NEJM199302043280503","article-title":"Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. TV","volume":"328","author":"Hentschel","year":"1993","journal-title":"Engl J Med"},{"key":"2024092814523273300_bib15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-116-9-705","article-title":"Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized control study","volume":"116","author":"Graham","year":"1992","journal-title":"Ann Intern Med"},{"key":"2024092814523273300_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM199302043280512","article-title":"Treatment of peptic ulcers caused by","volume":"328","author":"Graham","year":"1993","journal-title":"Helicobacter pylori. N Engl J Med"},{"key":"2024092814523273300_bib17","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1136\/gut.34.10.1344","article-title":"Acute perforated duodenal ulcer is not associated with Helicobacter pylori infection","volume":"34","author":"Reinbach","year":"1993","journal-title":"Gut"},{"key":"2024092814523273300_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(86)92940-5","article-title":"Rising frequency of ulcer perforation in elderly people in the United Kingdom","volume":"i","author":"Walt","year":"1986","journal-title":"Lancet"},{"key":"2024092814523273300_bib19","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/bjs.1800711012","article-title":"What has happened to perforated peptic ulcer?","volume":"71","author":"Watkins","year":"1984","journal-title":"Br J Surg"},{"key":"2024092814523273300_bib20","first-page":"491","article-title":"Omeprazole plus amoxicyllin: efficacy of various treatment regimens to eradicate Helicobacter pylori (comments)","volume":"88","author":"Lebenz","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2024092814523273300_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0016-5085(92)90095-G","article-title":"Factors influencing the eradication of Helicobacter pylori with triple therapy","volume":"102","author":"Graham","year":"1992","journal-title":"Gastroenterology"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800820325","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/82\/3\/360\/59409540\/bjs1800820325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/82\/3\/360\/59409540\/bjs1800820325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T14:52:39Z","timestamp":1727535159000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/82\/3\/360\/6167157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,3,1]]},"published-print":{"date-parts":[[1995,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800820325","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,3]]},"published":{"date-parts":[[1995,3,1]]}}}