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One infant with severe congenital anomalies received only palliative treatment. Of 26 with irresectable disease, pulsed cytotoxic chemotherapy (cisplatin and doxorubicin) enabled subsequent surgical excision in 22 and one child with persistent extensive intrahepatic disease was successfully treated by liver transplantation. Thus, with a policy of selective preoperative chemotherapy, 90 per cent of hepatoblastomas were resectable. There were no perioperative deaths from haemorrhage but one child died from an intraoperative tumour embolus. A total of 28 survivors, 27 of whom are disease-free, were followed for a median of 5 years. The cumulative probability of survival in patients treated with intent to cure was 67 per cent. Analysis of survival data suggested a favourable outcome for those with a pure fetal histological tumour subtype. These results demonstrate significant progress in the treatment of hepatoblastoma.<\/jats:p>","DOI":"10.1002\/bjs.1800820334","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:36:09Z","timestamp":1172957769000},"page":"386-391","source":"Crossref","is-referenced-by-count":91,"title":["Improved outcome for children with hepatoblastoma"],"prefix":"10.1093","volume":"82","author":[{"given":"M D","family":"Stringer","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hennayake","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E R","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Spitz","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Shafford","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mieli-Vergani","sequence":"additional","affiliation":[{"name":"Department of Hepatology, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Pathology, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Dicks-Mireaux","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Karani","sequence":"additional","affiliation":[{"name":"Department of Radiology, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Mowat","sequence":"additional","affiliation":[{"name":"Department of Hepatology, King's College Hospital , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Hospital for Sick Children , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"2024092814363265600_bib1","first-page":"389","article-title":"SIOPEL 1. 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