{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:28:40Z","timestamp":1776468520258,"version":"3.51.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Surgery, trauma and anaesthesia induce a state of transient immunosuppression. Laparoscopic cholecystectomy has several well documented clinical advantages over traditional cholecystectomy and provokes a lower acute phase response, thought to be a result of the smaller wound size. The influence of laparoscopic cholecystectomy (21 patients) and conventional open cholecystectomy (13 patients) upon components of the cell-mediated immune system was investigated. Cell-mediated immunity was studied by in vitro assays of T lymphocyte proliferation to different mitogens, and by natural killer cell cytotoxicity using a standard 51Cr release assay. Blood samples were taken before and 24 h after the start of the operation. In the sample taken after operation there was significant depression of T lymphocyte proliferation to phytohaemagglutinin (stimulation index 149.4 versus 33.3, P &amp;lt; 0.002), staphy-lococcal enterotoxin B (85.2 versus 52.6, P = 0.01) and toxic shock syndrome toxin (48.4 versus 14.8, P = 0.08) in the group of patients who underwent open surgery, but not in the group treated by laparoscopic surgery. There was a small but statistically insignificant decrease of natural killer cell cytotoxicity in both groups of patients. These findings suggest that laparoscopic cholecystectomy causes less depression of cell-mediated immunity than open cholecystectomy.<\/jats:p>","DOI":"10.1002\/bjs.1800820539","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:16:03Z","timestamp":1172960163000},"page":"677-680","source":"Crossref","is-referenced-by-count":49,"title":["Influence of laparoscopic and conventional cholecystectomy upon cell-mediated immunity"],"prefix":"10.1093","volume":"82","author":[{"given":"J P","family":"Griffith","sequence":"first","affiliation":[{"name":"Leeds Institute for Minimally Invasive Therapy and Centre for Digestive Diseases, General Infirmary, Leeds, Academic Unit of Surgery , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J","family":"Everitt","sequence":"additional","affiliation":[{"name":"Leeds Institute for Minimally Invasive Therapy and Centre for Digestive Diseases, General Infirmary, Leeds, Academic Unit of Surgery , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Lancaster","sequence":"additional","affiliation":[{"name":"Unit of Molecular Medicine, University of Leeds , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boylston","sequence":"additional","affiliation":[{"name":"Unit of Molecular Medicine, University of Leeds , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Richards","sequence":"additional","affiliation":[{"name":"Haematology Malignancy Diagnostic Service , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Scott","sequence":"additional","affiliation":[{"name":"Haematology Malignancy Diagnostic Service , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Benson","sequence":"additional","affiliation":[{"name":"Leeds Institute for Minimally Invasive Therapy and Centre for Digestive Diseases, General Infirmary, Leeds, Academic Unit of Surgery , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Sue-Ling","sequence":"additional","affiliation":[{"name":"Leeds Institute for Minimally Invasive Therapy and Centre for Digestive Diseases, General Infirmary, Leeds, Academic Unit of Surgery , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"McMahon","sequence":"additional","affiliation":[{"name":"Leeds Institute for Minimally Invasive Therapy and Centre for Digestive Diseases, General Infirmary, Leeds, Academic Unit of Surgery , Leeds,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,5,1]]},"reference":[{"key":"2024092816014760400_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bjs.1800780203","article-title":"Laparoscopic cholecystectomy","volume":"78","author":"Paterson-Brown","year":"1991","journal-title":"Br J Surg"},{"key":"2024092816014760400_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/lps.1992.2.81","article-title":"Open versus laparoscopic cholecystectomy: a retrospective comparative study","volume":"2","author":"Glinatsis","year":"1992","journal-title":"J Laparoendosc Surg"},{"key":"2024092816014760400_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0002-9610(91)90603-B","article-title":"The European experience with laparoscopic cholecystectomy","volume":"161","author":"Cuschieri","year":"1991","journal-title":"Am J Surg"},{"key":"2024092816014760400_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/bjs.1800780209","article-title":"Reduced postoperative hospitalization after laparoscopic chole cystectomy","volume":"78","author":"Grace","year":"1991","journal-title":"Br J Surg"},{"key":"2024092816014760400_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00000658-199106000-00016","article-title":"Open versus laparoscopic cholecystectomy. 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