{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:49:09Z","timestamp":1770749349575,"version":"3.50.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Japanese Ministry of Eductation","award":["02770806"],"award-info":[{"award-number":["02770806"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intact intestinal epithelium and associated lymphatic tissue act as body defences against luminal toxins. This barrier may become threatened or compromised in inflammatory bowel disease, leading to an increase in mucosal permeability and subsequent translocation of endotoxins. The effect of oral glutamine on gut mucosal ornithine decarboxylase activity and on endotoxin levels in portal vein blood was studied in a guinea-pig model of carrageenan-induced colitis. Despite failure to show induction of ornithine decarboxylase activity by glutamine administration, the mean endotoxin level of portal vein blood in guinea-pigs fed a glutamine-enriched elemental diet was 25.3 pg\/ml compared with 71.2 pg\/ml in animals given a standard elemental diet (P &amp;lt; 0.01). A glutamine-enriched elemental diet may be therapeutically beneficial in patients with inflammatory bowel disease.<\/jats:p>","DOI":"10.1002\/bjs.1800820611","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:00:54Z","timestamp":1172959254000},"page":"749-751","source":"Crossref","is-referenced-by-count":43,"title":["Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis"],"prefix":"10.1093","volume":"82","author":[{"given":"T","family":"Fujita","sequence":"first","affiliation":[{"name":"First Department of Surgery, Jikei University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Luke's International Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"2024092816195739000_bib1","first-page":"917","article-title":"The gut: a central organ after surgical stress","volume":"104","author":"Wilmore","year":"1988","journal-title":"Surgery"},{"key":"2024092816195739000_bib2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"20","author":"American College of Chest Physicians and Society of Critical Care Medicine Consensus Conference","year":"1992","journal-title":"Crit Care Med"},{"key":"2024092816195739000_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/bjs.1800800436","article-title":"Colonic bacteria and bacterial translocation in experimental colitis","volume":"80","author":"Gardiner","year":"1993","journal-title":"Br J Surg"},{"key":"2024092816195739000_bib4","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0140-6736(69)91802-9","article-title":"Portal bacteraemia in cases of ulcerative colitis submitted to colectomy","volume":"i","author":"Eade","year":"1969","journal-title":"Lancet"},{"key":"2024092816195739000_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/00365528009181475","article-title":"Endotoxin-induced microclots in ulcerative colitis and Crohn's disease","volume":"15","author":"Juhlin","year":"1980","journal-title":"Scand J Gastroenterol"},{"key":"2024092816195739000_bib6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/bjs.1800710821","article-title":"Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery","volume":"71","author":"Ambrose","year":"1984","journal-title":"Br J Surg"},{"key":"2024092816195739000_bib7","first-page":"147","article-title":"A study of endotoxemia in ulcerative colitis and Crohn's disease. 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