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Home visits to obtain full pedigree details took place for 123 women, and members of 24 families gave venous blood samples. The extracted DNA was typed by polymerase chain reaction amplification and the derived haplotypes submitted to linkage analysis which confirmed that in 12 families breast cancer susceptibility could be traced to BRCA1. The study demonstrates the number of women at risk of breast cancer in the population, illustrates the complexity of genetic analysis for hereditary breast cancer and demonstrates the problems of predictive analysis in clinical management.<\/jats:p>","DOI":"10.1002\/bjs.1800820826","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:38:11Z","timestamp":1172961491000},"page":"1086-1088","source":"Crossref","is-referenced-by-count":3,"title":["Hereditary breast cancer and linkage analysis to <i>BRCA1<\/i>"],"prefix":"10.1093","volume":"82","author":[{"given":"A G","family":"McKinley","sequence":"first","affiliation":[{"name":"Department of Surgery, Belfast City Hospital and Royal Victoria Hospital, The Queens University , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E H","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital and Royal Victoria Hospital, The Queens University , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A J","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Surgery, Belfast City Hospital and Royal Victoria Hospital, The Queens University , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Odling-Smee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Belfast City Hospital and Royal Victoria Hospital, The Queens University , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N C","family":"Nevin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital and Royal Victoria Hospital, The Queens University , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,8,1]]},"reference":[{"key":"2024092815582653100_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-1809.1991.tb00408.x","article-title":"Genetic epidemiology of breast cancer in Britain","volume":"55","author":"Iselius","year":"1991","journal-title":"Ann Hum Genet"},{"key":"2024092815582653100_bib2","first-page":"232","article-title":"Genetic analysis of breast cancer in the cancer and steroid hormone study","volume":"48","author":"Claus","year":"1991","journal-title":"Am J Hum Genet"},{"key":"2024092815582653100_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jmg.29.3.154","article-title":"Family history and risk of breast cancer","volume":"29","author":"Houlston","year":"1992","journal-title":"J Med Genet"},{"key":"2024092815582653100_bib4","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","article-title":"Linkage of early-onset familial breast cancer to chromosome 17q21","volume":"250","author":"Hall","year":"1990","journal-title":"Science"},{"key":"2024092815582653100_bib5","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. 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