{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:28:27Z","timestamp":1766485707892,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Health and Social Services"},{"DOI":"10.13039\/501100000692","name":"Royal College of Surgeons of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of the l-arginine-nitric oxide pathway in the pathogenesis of colonic inflammation was assessed using l-arginine and its competitive analogue N\u03c9-nitro-l-arginine methyl ester (l-NAME) in a rat model of colitis. In the first study oral l-arginine 2 per cent (control: 3.4 per cent l-glycine) was administered with and without l-NAME 100 mg\/l. Orally administered l-arginine increased colonic inflammation (P = 0.004) and decreased thymic weight (P = 0.0007). Addition of l-NAME reduced the colonic inflammation and prevented loss of body-weight (P &amp;lt; 0.04). In the second study l-NAME was administered orally in concentrations of 100, 200 and 500 mg\/l (control: no l-NAME). l-NAME 500 mg\/l reduced colonic inflammation and increased thymic weight and body-weight (P &amp;lt; 0.01). Thymic weight and body-weight correlated positively with the concentration of l-NAME administered orally (rs\u22650.3, P = 0.04). l-NAME l g\/l was administered topically as an enema (control: suspension agent). Topical l-NAME reduced colonic inflammation and increased thymic weight (P &amp;lt; 0.05). These results suggest that the l-arginine-nitric oxide pathway mediates colonic inflammation in this model.<\/jats:p>","DOI":"10.1002\/bjs.1800820913","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:00:08Z","timestamp":1172962808000},"page":"1188-1191","source":"Crossref","is-referenced-by-count":21,"title":["Manipulation of the <scp>l<\/scp>-arginine-nitric oxide pathway in experimental colitis"],"prefix":"10.1093","volume":"82","author":[{"given":"P J D","family":"Neilly","sequence":"first","affiliation":[{"name":"Department of Surgery, The Queen's University of Belfast , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Queen's University of Belfast , Belfast,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K 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