{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:08:10Z","timestamp":1767650890346},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Forty patients underwent total pancreatoduodenectomy for end-stage chronic pancreatitis. There were 34 men and six women of median age 39 (range 21\u201366) years. Alcoholism was the major aetiological agent (30 patients), and five patients had had previous acute idiopathic pancreatitis. The overwhelming indication for operation was severe abdominal pain, complicated by failing exocrine and endocrine function. Resection was performed in one (17 patients) or two (23) stages, following previous proximal (seven) or distal (16) pancreatectomy; progression from partial to total pancreatectomy occurred over an interval of 8\u201396 (median 15) months. A further six patients had undergone previous pseudocyst or duct drainage procedures. The pylorus was preserved in 28 patients and the spleen in ten. Median operating time was 6 (range 2\u00b15\u20138\u00b15) h and median blood loss 2000 (range 500\u201316000) ml. There were two hospital deaths and three patients required reoperation. Of 38 survivors, 30 obtained complete or substantial relief of pain. There were 15 late deaths at 2\u00b15\u2013120\u00b10 months after operation, 13 in the alcohol group and 11 disease-related. Total pancreatectomy can relieve the intractable pain of chronic pancreatitis at the cost of possible premature death from continuing alcohol abuse.<\/jats:p>","DOI":"10.1002\/bjs.1800821037","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:17:34Z","timestamp":1172956654000},"page":"1409-1412","source":"Crossref","is-referenced-by-count":39,"title":["Role of total pancreatectomy in the treatment of patients with end-stage chronic pancreatitis"],"prefix":"10.1093","volume":"82","author":[{"given":"W R","family":"Fleming","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School , Du Cane Road, London W12 0NN,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C N","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Postgraduate Medical School , Du Cane Road, London W12 0NN,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"2024092815135895200_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF01670540","article-title":"Observations and surgical management of chronic pancreatitis in the British Isles: a review of the twentieth century","volume":"14","author":"MacLaren","year":"1990","journal-title":"World J Surg"},{"key":"2024092815135895200_bib2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/gut.32.11.1401","article-title":"National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960-1988","volume":"32","author":"Johnson","year":"1991","journal-title":"Gut"},{"key":"2024092815135895200_bib3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/bjs.1800701212","article-title":"Coeliac plexus block for pain in pancreatic cancer and chronic pancreatitis","volume":"70","author":"Leung","year":"1983","journal-title":"Br J Surg"},{"key":"2024092815135895200_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00000658-197809000-00006","article-title":"Total pancreatectomy for end-stage chronic pancreatitis","volume":"188","author":"Braasch","year":"1978","journal-title":"Ann Surg"},{"key":"2024092815135895200_bib5","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bjs.1800741013","article-title":"Total pancreatectomy for chronic pancreatitis","volume":"74","author":"Cooper","year":"1987","journal-title":"Br J Surg"},{"key":"2024092815135895200_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0002-9610(89)90439-X","article-title":"Treatment of chronic alcoholic pancreatitis by pancreatic resection","volume":"157","author":"Keith","year":"1989","journal-title":"Am J Surg"},{"key":"2024092815135895200_bib7","first-page":"223","article-title":"Total pancreatectomy for chronic pancreatitis","volume":"160","author":"Kiviluoto","year":"1985","journal-title":"Surg Gynecol Obstet"},{"key":"2024092815135895200_bib8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/archsurg.1988.01400310029004","article-title":"Chronic pancreatitis. Results of Whipple's resection and total pancreatectomy","volume":"123","author":"Stone","year":"1988","journal-title":"Arch Surg"},{"key":"2024092815135895200_bib9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/gut.29.3.358","article-title":"Total pancreatectomy for chronic pancreatitis","volume":"29","author":"Linehan","year":"1988","journal-title":"Gut"},{"key":"2024092815135895200_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/00000658-199111000-00007","article-title":"Total pancreatectomy with preservation of the duodenum and pylorus for chronic pancreatitis","volume":"214","author":"Easter","year":"1991","journal-title":"Ann Surg"},{"key":"2024092815135895200_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00000658-197909000-00006","article-title":"Surgical treatment of chronic pancreatitis. Twenty-two years' experience","volume":"190","author":"Traverso","year":"1979","journal-title":"Ann Surg"},{"key":"2024092815135895200_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01658311","article-title":"Results of partial and total pancreaticoduodenectomy in 117 patients with chronic pancreatitis","volume":"5","author":"Gall","year":"1981","journal-title":"World J Surg"},{"key":"2024092815135895200_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0002-9610(81)90007-6","article-title":"Ductal drainage or resection for chronic pancreatitis","volume":"141","author":"Taylor","year":"1981","journal-title":"Am J Surg"},{"key":"2024092815135895200_bib14","first-page":"608","article-title":"Chronic pancreatitis: long-term surgical results of pancreatic duct drainage, pancreatic resection, and near-total pancreatectomy and islet autotransplantation","volume":"96","author":"Morrow","year":"1984","journal-title":"Surgery"},{"key":"2024092815135895200_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01670549","article-title":"Pancreaticoduodenectomy (Whipple resection) in the treatment of chronic pancreatitis","volume":"14","author":"Howard","year":"1990","journal-title":"World J Surg"},{"key":"2024092815135895200_bib16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/bjs.18004016003","article-title":"Total pancreatectomy","volume":"40","author":"Gourevitch","year":"1952","journal-title":"Br J Surg"},{"key":"2024092815135895200_bib17","first-page":"285","article-title":"Nerve block in pancreatic pain","volume":"156","author":"Bengtsson","year":"1990","journal-title":"Acta Chirurgica Scandinavica"},{"key":"2024092815135895200_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF01670538","article-title":"The pathology of chronic pancreatitis","volume":"14","author":"Singh","year":"1990","journal-title":"World J Surg"},{"key":"2024092815135895200_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/bjs.1800711008","article-title":"Drainage operations in chronic pancreatitis","volume":"71","author":"Cooper","year":"1984","journal-title":"Br J Surg"},{"key":"2024092815135895200_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/BF01670548","article-title":"Long-term results of side-to-side pancreaticojejunostomy","volume":"14","author":"Greenlee","year":"1990","journal-title":"World J Surg"},{"key":"2024092815135895200_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0016-5085(80)90143-2","article-title":"Long-term patency, pancreatic function, and pain relief after lateral pancreaticojejunostomy for chronic pancreatitis","volume":"79","author":"Warshaw","year":"1980","journal-title":"Gastroenterology"},{"key":"2024092815135895200_bib22","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(24)05129-1","article-title":"Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients","volume":"86","author":"Ammann","year":"1984","journal-title":"Gastroenterology"},{"key":"2024092815135895200_bib23","first-page":"339","volume-title":"Surgery of the Pancreas. Section 5: Chronic Pancreatitis","author":"Russell","year":"1993"},{"key":"2024092815135895200_bib24","first-page":"347","article-title":"Is proximal pancreatoduodenectomy with pyloric preservation superior to total pancreatectomy?","volume":"105","author":"McAfee","year":"1989","journal-title":"Surgery"},{"key":"2024092815135895200_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00000658-198801000-00009","article-title":"The complications of pancreatectomy","volume":"207","author":"Trede","year":"1988","journal-title":"Ann Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800821037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/82\/10\/1409\/59412622\/bjs1800821037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/82\/10\/1409\/59412622\/bjs1800821037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T15:14:04Z","timestamp":1727536444000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/82\/10\/1409\/6167443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10,1]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1995,10,1]]},"published-print":{"date-parts":[[1995,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800821037","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1995,10]]},"published":{"date-parts":[[1995,10,1]]}}}