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The present study was designed to examine this role in experimental animals. Serum levels of total cholesterol, triglyceride and high-density lipoprotein (HDL) cholesterol were determined in 32 rats. The spleen was removed in 16 rats and the remaining 16 were sham operated. Half of the splenectomized and half of the remaining rats were fed on a diet rich in fat and the two other subgroups were fed normal chow. Blood tests were performed before, and 3 and 6 months after operation. A significant increase in serum triglyceride and decrease in serum HDL cholesterol levels was observed after splenectomy in rats fed normal chow compared with sham-operated rats. An increase in serum triglyceride and a decrease in serum HDL cholesterol levels was observed in both groups of rats fed normal chow plus high-fat cheese. However, these changes were more pronounced in splenectomized rats. These findings suggest that the spleen has a role in lipid metabolism in rats and may therefore influence atherosclerosis.<\/jats:p>","DOI":"10.1002\/bjs.1800821230","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:35:07Z","timestamp":1172961307000},"page":"1675-1677","source":"Crossref","is-referenced-by-count":58,"title":["Role of the spleen in lipid metabolism"],"prefix":"10.1093","volume":"82","author":[{"given":"M","family":"Fatouros","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Ioannina, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Bourantas","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bairaktari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Elisaf","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Tsolas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Cassioumis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Ioannina, University Hospital , Ioannina,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,12,1]]},"reference":[{"key":"2024092815110974200_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0140-6736(77)90132-5","article-title":"Splenectomy and subsequent mortality in veterans of the 1939\u201345 war","volume":"16","author":"Robinette","year":"1977","journal-title":"Lancet"},{"key":"2024092815110974200_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000441-198601000-00006","article-title":"Increased low-density lipoprotein levels after splenectomy: a role for the spleen in cholesterol metabolism in myeloproliferative disorders","volume":"291","author":"Aviram","year":"1986","journal-title":"Am J Med Sci"},{"key":"2024092815110974200_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/000331978803900602","article-title":"Effects of splenectomy on serum lipids and experimental atherosclerosis","volume":"39","author":"Asai","year":"1988","journal-title":"Angiology"},{"key":"2024092815110974200_bib4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0002-9149(92)90550-I","article-title":"Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). 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