{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:07:13Z","timestamp":1770822433378,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study determined whether the long-term outcome of patients with obstructing colorectal cancer could be related to conventional pathological prognostic variables or to other clinical, operative or histological features. Ninety-eight patients with bowel obstruction who had undergone potentially curative surgery and survived the postoperative period were studied. Features related to poor long-term outcome after a median follow-nup of 5 years included bowel perforation at initial operation (P = 0.007), advanced tumour stage (P&amp;lt; 0.001), poor tumour differentiation (P = 0.02), mucin production by tumour (P = 0.004) and the presence of vascular (P = 0.08) and neural (P = 0.004) invasion. Outcome was not significantly related to the seniority of the operating surgeon (P = 0.52), even when this was adjusted for potentially confounding variables (adjusted hazard rate ratio for trainee surgeons 1.4 (95 per cent confidence interval 0.9\u20132.4), P = 0.16). Conventional prognostic features may help to identify the majority of patients with obstructed colorectal cancer at high risk of tumour recurrence and death.<\/jats:p>","DOI":"10.1002\/bjs.1800830114","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T07:26:33Z","timestamp":1172733993000},"page":"46-50","source":"Crossref","is-referenced-by-count":97,"title":["Long-term outcome following curative surgery for malignant large bowel obstruction"],"prefix":"10.1093","volume":"83","author":[{"given":"H E","family":"Mulcahy","sequence":"first","affiliation":[{"name":"Gastroenterology and Liver Unit, St Vincent's Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Skelly","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Unit, St Vincent's Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Vincent's Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Gastroenterology and Liver Unit, St Vincent's Hospital , Dublin,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,1,1]]},"reference":[{"key":"2024092815564614400_bib1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/0002-9610(82)90050-2","article-title":"Prognosis in patients with obstructing colorectal carcinoma","volume":"143","author":"Ohman","year":"1982","journal-title":"Am J Surg"},{"key":"2024092815564614400_bib2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/bjs.1800641015","article-title":"The treatment of colonic cancer presenting with intestinal obstruction","volume":"64","author":"Irvin","year":"1977","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/bjs.1800730320","article-title":"Emergency presentation and mortality from colorectal cancer in the elderly","volume":"73","author":"Waldron","year":"1986","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/bjs.1800720417","article-title":"Malignant large bowel obstruction","volume":"72","author":"Phillips","year":"1985","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02555634","article-title":"Survival in acute obstructing colorectal carcinoma","volume":"27","author":"Umpleby","year":"1984","journal-title":"Dis Colon Rectum"},{"key":"2024092815564614400_bib6","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/bjs.1800790739","article-title":"Elective versus emergency surgery for patients with colorectal cancer","volume":"79","author":"Anderson","year":"1992","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/bjs.1800780216","article-title":"Outcome after emergency surgery for cancer of the large intestine","volume":"78","author":"Runkel","year":"1991","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib8","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(86)90422-8","article-title":"Prediction of outcome after curative resection for large bowel cancer","volume":"ii","author":"Fielding","year":"1986","journal-title":"Lancet"},{"key":"2024092815564614400_bib9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/bjs.1800720909","article-title":"A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer","volume":"72","author":"Chapuis","year":"1985","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/bmj.2.6189.515","article-title":"Large-bowel obstruction caused by cancer: a prospective study","volume":"ii","author":"Fielding","year":"1979","journal-title":"BMJ"},{"key":"2024092815564614400_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1445-2197.1983.tb02430.x","article-title":"Terminology and classification of colorectal adenocarcinoma: the Australian clinico\u2013 pathological staging system","volume":"53","author":"Davis","year":"1983","journal-title":"Aust N Z J Surg"},{"key":"2024092815564614400_bib12","first-page":"1022","article-title":"Mucinous carcinomas of the colon and rectum. An analysis of 62 stage B and C lesions","volume":"115","author":"Connelly","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"2024092815564614400_bib13","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/1097-0142(19880301)61:5<1018::AID-CNCR2820610527>3.0.CO;2-H","article-title":"Vascular and neural invasion in colorectal carcinoma. Incidence and prognostic significance","volume":"61","author":"Krasna","year":"1988","journal-title":"Cancer"},{"key":"2024092815564614400_bib14","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"1980"},{"key":"2024092815564614400_bib15","first-page":"513","article-title":"Multivariate analysis of morbidity and mortality from the initial surgical management of obstructing carcinoma of the colon","volume":"174","author":"Leitman","year":"1992","journal-title":"Surg Gynecol Obstet"},{"key":"2024092815564614400_bib16","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/0002-9610(74)90302-X","article-title":"Management of severe obstruction of the large bowel due to malignant disease","volume":"127","author":"Welch","year":"1974","journal-title":"Am J Surg"},{"key":"2024092815564614400_bib17","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/1097-0142(19810315)47:6<1424::AID-CNCR2820470630>3.0.CO;2-O","article-title":"The relationship of survival to staging and grading of colorectal carcinoma: a prospective study of 503 cases","volume":"47","author":"Newland","year":"1981","journal-title":"Cancer"},{"key":"2024092815564614400_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/bjs.1800720915","article-title":"Peculiarities of mucinous colorectal carcinoma","volume":"72","author":"Umpleby","year":"1985","journal-title":"Br J Surg"},{"key":"2024092815564614400_bib19","volume-title":"The report of the National Confidential Enquiry into Perioperative Deaths 1991\/1992","author":"Campling","year":"1993"},{"key":"2024092815564614400_bib20","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1136\/bmj.302.6791.1501","article-title":"Impact of variability among surgeons on postoperative morbidity and mortality and ultimate survival","volume":"302","author":"McArdle","year":"1991","journal-title":"BMJ"},{"key":"2024092815564614400_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0140-6736(95)90340-2","article-title":"Long-term results of single course of adjuvant intraportal chemotherapy for colorectal cancer","volume":"345","author":"Swiss Group for Clinical Cancer Research (SAKK)","year":"1995","journal-title":"Lancet"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800830114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800830114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/83\/1\/46\/59417220\/bjs1800830114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/83\/1\/46\/59417220\/bjs1800830114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T15:56:59Z","timestamp":1727539019000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/83\/1\/46\/6167388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1996,1,1]]},"published-print":{"date-parts":[[1996,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800830114","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,1]]},"published":{"date-parts":[[1996,1,1]]}}}