{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:59:56Z","timestamp":1773284396306,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fifty human immunodeficiency virus (HIV)-infected patients with perianal sepsis were studied. Seven (14 per cent) had serious septic complications, four patients with severe necrotizing gangrene, and three with abscesses in the mediastinum, liver and brain respectively. CD4 + lymphocyte counts were significantly lower in patients with severe septic complications as compared with those with uncomplicated perianal sepsis (P&amp;lt;0\u00b705). In patients with HIV presenting with rare (metastatic) abscesses, perianal sepsis must always be kept in mind as a possible focus. Although HIV-infected patients have a limited life expectancy perianal fistulas and abscesses should be aggressively treated, because of the high risk of severe complications.<\/jats:p>","DOI":"10.1002\/bjs.1800830616","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:24:09Z","timestamp":1172859849000},"page":"778-780","source":"Crossref","is-referenced-by-count":17,"title":["Severe complications of perianal sepsis in patients with human immunodeficiency virus"],"prefix":"10.1093","volume":"83","author":[{"given":"E C J","family":"Consten","sequence":"first","affiliation":[{"name":"Department of Surgery, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F M","family":"Slors","sequence":"additional","affiliation":[{"name":"Department of Surgery, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Danner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R A","family":"Sars","sequence":"additional","affiliation":[{"name":"Department of Surgery, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Obertop","sequence":"additional","affiliation":[{"name":"Department of Surgery, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J B","family":"van Lanschot","sequence":"additional","affiliation":[{"name":"Department of Surgery, AIDS Unit, Academic Medical Centre , Meibergdreef 9, 1105 AZ Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,6,1]]},"reference":[{"key":"2024092910102615500_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/bjs.1800770506","article-title":"Male homo sexuality, HIV infection and colorectal surgery","volume":"77","author":"Scholefield","year":"1990","journal-title":"Br J Surg"},{"key":"2024092910102615500_bib2","first-page":"366","article-title":"General operative aspects of human immunodeficiency virus infection and acquired immunodeficiency syndrome","volume":"180","author":"Consten","year":"1995","journal-title":"J Am Coll Surg"},{"key":"2024092910102615500_bib3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02055466","article-title":"Abdominal and anorectal surgery and the acquired immune deficiency syndrome in heterosexual intravenous drug users","volume":"33","author":"Wolkomir","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/bjs.1800820710","article-title":"Local excision and mucosal advancement for anorectal ulceration in patients infected with human immunodeficiency virus","volume":"82","author":"Consten","year":"1995","journal-title":"Br J Surg"},{"key":"2024092910102615500_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0950-3528(92)90020-F","article-title":"Anorectal HIV infection and AIDS: diagnosis and management","volume":"6","author":"Sim","year":"1992","journal-title":"Baillieres Clin Gastroenterol"},{"key":"2024092910102615500_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02050588","article-title":"Anorectal surgery in the HIV positive patient: update","volume":"34","author":"Safavi","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/bjs.1800770808","article-title":"Surgical management of anorectal disease in HIV-positive homosexuals","volume":"77","author":"Miles","year":"1990","journal-title":"Br J Surg"},{"key":"2024092910102615500_bib8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0891-5520(20)30474-8","article-title":"Surgical care of HIV-infected patients","volume":"6","author":"Macho","year":"1992","journal-title":"Infect Dis Clin North Am"},{"key":"2024092910102615500_bib9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/BF02139224","article-title":"Sexually transmitted disease of the colon, rectum, and anus","volume":"33","author":"Wexner","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF02555318","article-title":"The surgical management of anorectal diseases in AIDS and pre-AIDS patients","volume":"29","author":"Wexner","year":"1986","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib11","first-page":"455","article-title":"Abdominal pain and anorectal surgery in the HIV-infected patient","volume":"34","author":"Barone","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib12","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1001\/archsurg.1991.01410340109015","article-title":"Wound healing after anorectal surgery in human immunodeficiency virus-infected patients","volume":"126","author":"Burke","year":"1991","journal-title":"Arch Surg"},{"key":"2024092910102615500_bib13","first-page":"397","volume-title":"Surgery of the Anus, Rectum and Colon","author":"Keighley","year":"1993"},{"key":"2024092910102615500_bib14","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0022-5347(17)49946-0","article-title":"Fournier's gangrene: 5 patients treated with hyperbaric oxygen","volume":"132","author":"Riegels-Nielsen","year":"1984","journal-title":"J Urol"},{"key":"2024092910102615500_bib15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/BF02554263","article-title":"Fournier's gangrene following a perianal abscess","volume":"29","author":"DiFalco","year":"1986","journal-title":"Dis Colon Rectum"},{"key":"2024092910102615500_bib16","first-page":"184","article-title":"Fournier's gangrene: the need for early recognition and radical surgical debridement","volume":"43","author":"de Roos","year":"1991","journal-title":"Neth J Surg"},{"key":"2024092910102615500_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1464-410X.1992.tb15669.x","article-title":"New approach to the management of Fournier's gangrene","volume":"70","author":"Attah","year":"1992","journal-title":"Br J Urol"},{"key":"2024092910102615500_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-5347(17)50351-1","article-title":"Fournier's gangrene: report of 20 patients","volume":"131","author":"Spirnak","year":"1984","journal-title":"J Urol"},{"key":"2024092910102615500_bib19","first-page":"339","article-title":"Fournier's gangrene of scrotum in a patient with AIDS","volume":"67","author":"Murphy","year":"1991","journal-title":"Genitourin Med"},{"key":"2024092910102615500_bib20","first-page":"2637","volume-title":"Dermatology in General Medicine","author":"Johnson","year":"1993"},{"key":"2024092910102615500_bib21","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/BF02048332","article-title":"Anorectal surgery in HIV-infected patients; clinical outcome in relation with immune status","volume":"38","author":"Consten","year":"1995","journal-title":"Dis Colon Rectum"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800830616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800830616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/83\/6\/778\/59428146\/bjs1800830616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/83\/6\/778\/59428146\/bjs1800830616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T11:23:03Z","timestamp":1727608983000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/83\/6\/778\/6167605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1996,6,1]]},"published-print":{"date-parts":[[1996,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800830616","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,6]]},"published":{"date-parts":[[1996,6,1]]}}}